What do we know about perioperative hypersensitivity reactions and what can we do to improve perioperative safety?

Figures & data

Table 1. Main causative agents of perioperative hypersensitivity events in several studies.

Laxenaire et al.	1997–1998	France	n = 467	Neuromuscular blocking agents-69.2%, Latex-12.1%, Antibiotics-8.0%, Hypnotics-3.7%, Opioids-1.4%, Colloids-2.7%
Mertes et al.	1999–2000	France	n = 789	Neuromuscular blocking agents-58.2%, Latex-16.7%, Antibiotics-15.1%, Hypnotics-3.4%, Opioids-1.3%, Colloids-4.0%
Dong et al.	2005–2007	France	n = 1253	Neuromuscular blocking agents-47.4%, Latex-20%, Antibiotics-18.1%, Hypnotics-1.1%, Opioids-2.2%, Colloids-2.3%
Ebo et al.	2001–2018	Belgium	n = 568	Neuromuscular blocking agents-30.9%, Latex-13.5%, Antibiotics-10.5%, Chlorhexidine −7.7%
Iammatteo et al.	2009–2017	USA	n = 34	Hypnotics-38%, Neuromuscular blocking agents-26%, Beta lactams-14%, Opioids-8%, Local anaesthetics-6%, Latex-5%, Ondansetron-3%
Meng et al.	2013–2016	United Kingdom	n = 31	Antibiotics-52.3%, Neuromuscular blocking agents-38.1%, Morphine-4.8%, Colloids-4.8%
Harper et al.	2018	United Kingdom	n = 266	Antibiotics-47.2%, Neuromuscular blocking agents-32.6%, Chlorhexidine-9%, Patent blue dye-4.5%

Authors, period, country, and the number of cases are presented.

Table 2. The incidence of neuromuscular blocking agents perioperative hypersensitivity events in several studies.

Sadleir et al.	2002–2011	Australia	n = 80	8.0:100 000 administrations over the 10 yr period for rocuronium 2.8:100 000 administrations over the 10 yr period for vecuronium 4.01:100 000 administrations over the 10 yr period for atracurium
Reedy et al^]	2006–2012	New Zealand	n = 21	1:2 079 administrations for succinylocholine 1: 2 498 administrations for rocuronium 1: 22 450 administrations for atracurium
Harper et al.	2018	United Kingdom	n = 266	1: 19 070 administrations for neuromuscular blocking agents 1: 9 006 administrations for succinylcholine 1: 17 002 administrations for rocuronium 1: 24 111 administrations for atracurium

Authors, period, country, and the number of cases are presented.