The ability of tidal volume challenge test to predict early post-operative acute kidney injury and intra-operative hypotension in laparoscopic abdominal surgeries

Figures & data

Table 1. Patients characteristics, clinical characteristics, comorbid conditions, and type of operation.

			AKI group (n = 15)	Non-AKI group (n = 55)	P
Age (years)			53.1 ± 9.11	35 ± 10.152	0.38
Sex	Female		11(15.71%)	4 (5.71%)	0.04
	Male		4 (5.71%)	11 (15.71%)
Body weight (Kg)			88.53 ± 23.45	80.47 ± 13.61	0.78
Height (cm)			169.4 ± 8.03	171.47 ± 7.22	0.08
BMI (kg/m^2)			34 ± 11.09	28.1 ± 5.66	1
Vital measurements
Baseline serum creatinine (mg/dL)			0.74 ± 0.16	0.75 ± 0.15	1
HR (bpm)			92.3 ± 6.78	84.67 ± 6.62	0.124
SBP (mmHg)			142.5 ± 10.81	125.8 ± 12.41	0.567
DBP (mmHg)			83.3 ± 7.94	72.9 ± 7.46	0.074
Comorbid conditions
DM			2 (2.86%)	5 (7.14%)	0.637
Dyslipidemia			0 (0%)	4 (5.71%)	0.571
Hypertension			3 (4.29%)	19 (27.14%)	0.359
ASA status		I	4 (5.14%)	46 (65.71%)	<0.0001*
		II	11 (15.71%)	9 (12.86%)
Type of operation
Gynecological surgery			2 (2.86%)	7 (10%)	1
Colorectal surgery			3 (4.29%)	3 (4.29%)	1.108
Upper abdomen surgery			7 (10%)	14 (20%)	0.125
Lower abdomen, surgery			3 (4.29%)	31 (44.29%)	0.019

Data exhibited as mean ± SD or frequency (%) or median (IQR). *Significant p value < 0.05, BMI: body mass index, DM: diabetes mellitus, HR: heart rate, SBP: systolic blood pressure, DBP: diastolic blood pressure, ASA: American Society of Anesthesiologists.

Figure 1. Subject disposition for the study.

Table 2. Analysis of intra-operative predictors.

	OR	P
TVC	2.305	0.052
Exposure index	1.003	0.034*
Baseline UNGAL	1.048	0.366

CI: confident interval, OR: Odds ratio, *significant p value < 0.05, TVC: tidal volume challenge, UNGAL: neutrophil gelatinase-associated lipocalin in urine.

Figure 2. The AUC for (a) baseline neutrophil gelatinase-associated lipocalin in urine (UNGAL), (b) exposure index, (c) tidal volume challenge (TVC).

Table 3. Relationship between TVC and hypotension frequency.

	Coefficient estimate	P
TVC	0.499	0.031*

Data are presented as median (IQR). *significant < 0.05, TVC: tidal volume challenge.