Figures & data
Table 1. Overview of potential antidepressant development approaches.
Table 2. K-Opioid receptor antagonists under development for MDD.
Figure 1. Kappa opioid receptor function.1. The receptor is inactive as no ligand is bound to the extracellular binding site. 2. A ligand binds to the extracellular binding site. 3. There is a resulting conformational change in the receptor. GDP is exchanged for GTP on the alpha subunit. Secondary messaging within the cell begins. Key: α, β, γ = alpha, beta, gamma subunit, respectively. GDP= guanine diphosphate. GTP= guanine triphosphate.
