Maternal serum interleukin-1β, FoxO1 and Sestrin2 levels in predicting preterm delivery

Figures & data

Figure 1. IL-1β levels in the groups.

Figure 2. FoxO1 levels in the groups.

Figure 3. Sesn2 levels in the groups.

Table 1. Maternal and fetal characteristics of the study population.

	Preterm(n:27)	Term (n:27)	Control (n:26)	p^1	p^2	p^3
Age (years)	27.62 ± 4.5	28.11 ± 4.1	27.93 ± 3.9	1.0	1.0	1.0
Gestational age at
blood sampling (weeks)	32.46 ± 1.1	33.1.6 ± 1.6	32.56 ± 1.7	0.486	0,679	1.0
Body mass index at
blood sampling (kg/m^2)	31.2 ± 4.8	31.9 ± 4.6	27.9 ± 1.6	0,013*	0,002*	1,0
Platelets (×10^9/I)	215.8 ± 62.4	195.4 ± 83.9	226.5 ± 61.4	1,0	0,349	0,865
MPV (fL)	91.04 ± 1.7	77.67 ± 1.4	71.78 ± 0.5	<.000*	<.005*	<.005*
Gestational age at
delivery (weeks)	33.08 ± 1.5	38.04 ± 0.9	38.22 ± 0.9	1.0	<.000*	.<000*
Birth weight (g)	2567.62 ± 314.8	3262.22 ± 188.9	3257.59 ± 168.1	1.0	<.000*	<.000*
Hb (g/dL)	13 ± 5.1	12 ± 2.7	12 ± 6.3	0.532	0.661	0.583
WBC (×10^3 /mm^3)	11.7 ± 1.6	12.2 ± 1.5	10.8 ± 2.2	0.548	0.536	0.511
CRP (mg/dL)	1.5 ± 0.6	1.1 ± 0.9	1.3 ± 1.1	0.751	0.858	0.7
Sesn 2 (ng/mL)	1.98 ± 0.76	5.90 ± 1.59	22.82 ± 3.097	.000*	.000 *	.000*
FoxO1 (ng/mL)	29.07 ± 6.23	12.91 ± 5.45	3.23 ± 1.122	.000*	.000*	.000*
IL-1β (pg/mL)	95.64 ± 12.75	47.36 ± 16.55	20.24 ± 2.76	.000*	.000*	.000*

P1: PD-control; P2: TD-control; P3: PD-TD. Data is given as n (%), means ± SD. p < 0.5.

Values are given as mean ± SD or number (%) unless otherwise indicated. BMI, body mass index; MPV, mean platelet volume; Group means were compared by ANOVA, followed by post hoc analyses for two group pairwise comparisons with Bonferroni‘s correction for multiple testing. A p-value of less than 0.05 is considered statistically significant.

Table 2. Comparison of term group (term delivery + control) and preterm groups.

	TD + Control (n = 53)	Preterm (n = 27)	p
Sesn2	4.67 ± 1.5	1.98 ± 0.76	.000
FoxO1	10,78 ± 5,41	29.07 ± 6.23	.000
IL-1β	41,48 ± 16,55	95.64 ± 12.76	.000

Table 3. Correlation analyses between maternal serum IL-1β, Foxo1, and Sesn2 all other parameters in whole groups.

	IL-1β		FoxO1		Sesn2
	p	r	p	r	p	r
Gestational week at delivery (weeks)	.000	−0.722	.000	−0.625	.000	0.507
Birth weight (g)	.000	−0.786	.000	−0.649	.000	0.409
Cervical length	.000	−0.459	.000	−0.769	.004	0.387
Body mass index at blood sampling(kg/m^2)	.002	0.578	.001	0.647	.002	−0.695
MPV	.000	0.672	0.000	0.676	.000	−0.572
IL1-β	–	–	.000	0.858	.000	−0.798
FoxO1	.001	0.373	–	–	.008	−0.296
Sesn2	.000	−0.543	.001	0.373	–	–

Figure 4. The ROC curve analysis of maternal serum IL-1β and FoxO1 concentration for predicting delivery within 48–72 h in threatened preterm labor.

Figure 5. The ROC curve analysis of maternal serum Sesn2 concentration for predicting delivery within 48–72 h in threatened preterm labor.

Data availability statement

All data generated or analyzed during this study are included in this article. Further inquiries can be directed to the corresponding author at [email protected]