Figures & data
Figure 1. The volcano plot and heat map of all DEGs and DMGs. (a) The volcano plot of all DEGs; (b) the heat map of all DEGs; and (c) the volcano plot of all DMGs.
Figure 2. The Venn diagram of 81 hypermethylated-down-regulated genes (a) and 121 hypomethylated-up-regulated genes (b).
Table 1. Identification of 9 core hypermethylated-low expression genes.
Table 2. Identification of 8 core hypomethylated-high expression genes.
Figure 3. PPI networks of 81 hypermethylated-low expression genes and 121 hypomethylated-high expression genes. (a) PPI network of 81 hypermethylated-low expression genes; (b) PPI network of 9 hypermethylated-low expression genes; (c) PPI network of 121 hypomethylated-high expression genes; (d) PPI network of 8 hypomethylated-high expression genes.
Figure 4. Functional analysis of 81 hypermethylated-low expression genes. (a) GO analysis; (b) KEGG analysis.
Figure 5. GO analysis of 121 hypomethylated-high expression genes.
Figure 6. The ROC curves of CD247, CCR7, CD5, IKZF1, SLAMF1, IL2RB, CD3E, CD7, IL7R, TREM1, AQP9, CD300LF, CLEC12A, NOD2, IRAK3, NLRP3, LYZ, HEBP2 and NOSIP in COPD.
Figure 7. Expression validations of CD247, CCR7, IKZF1, CD7, AQP9, NOD2 and IRAK3 by RT-PCR. *p value < 0.05; **p value < 0.01; ***p value < 0.001.
Figure 8. Expression validations of CD247, CCR7, CD5, IKZF1, SLAMF1, CD3E, IL7R, AQP9, NOD2, IRAK3, and NOSIP in GSE94916 dataset. *p value < 0.05; **p value < 0.01; ns: not significant.
Supplemental Material
Download Zip (774.8 KB)Availability of data and materials
Data are available in the article.