Association of serum 25-Hydroxy Vitamin D level with lipid, lipoprotein, and apolipoprotein level

Figures & data

Table 1. Clinical characteristics of study population

Variable	Vit D3 <30 ng/ml	Vit D3 >30 ng/ml	P
Gender (men), n(%)	14(43.8%)	32(48.5%)	0.508
Age,years	59.3 ± 2.9	66.4 ± 1.9	0.037*
BMI,kg/m2	32.6 ± 1.2	28.3 ± 0.6	0.001*
HbA1c,%	6.30 ± 0.21	5.94 ± 0.08	0.115
UA, mg/dL	6.16 ± 0.33	5.75 ± 0.19	0.251
TSH, μlU/mL	2.88 ± 0.33	2.41 ± 0.18	0.216
Hs-CRP, mg/L	18.3 ± 12.7	6.5 ± 2.6	0.371
LVEF, %	53.7 ± 2.8	57.2 ± 1.5	0.230
Cr, mg/dL	1.04 ± 0.09	0.98 ± 0.03	0.440
DM, n(%)	7(20.0)	21(31.8)	0.207
CAD, n(%)	13(38.2)	17(25.8)	0.197
HTN, n (%)	19(52.3)	35(53.0)	0.904
Statin, n (%)	19(55.9)	36(59.0)	0.767

Data are presented as mean ± standard error for continuous variables and number(percentage) for categorical variables. **, P < 0.01, *, P < 0.05.

BMI, body mass index; HbA1c, hemoglobin A1c; UA, uric acid; TSH, Thyroid-stimulating hormone; FFA, free fatty acid; hsCRP, high-sensitive C-reactive protein; LVEF, left ventricular ejection fraction; Cr, Serum creatinine; DM, diabetes mellitus; CAD, coronary artery disease; HTN, hypertension.

Table 2. Association of Vit D3 level with lipid, lipoprotein and apolipoprotein level

Lipid parameter	Vit D3		P value	Pearson correlation	P value
	<30 ng/ml	≥30 ng/ml
TC	175.6 ± 6.3	163.3 ± 5.2	0.147	−0.250	0.015*
LDL-C	111.4 ± 5.3	96.9 ± 3.5	0.021*	−0.259	0.011*
HDL-C	45.0 ± 1.6	51.0 ± 2.1	0.024*	0.132	0.203
TG	163.7 ± 14.3	120.9 ± 7.6	0.004**	−0.350	0.001**
Non-HDL-C	130.5 ± 5.6	112.5 ± 4.2	0.011*	−0.298	0.004**
LDL-P	1669.2 ± 79.9	1377.4 ± 57.9	0.004**	−0.324	0.001**
sLDL-P	958.7 ± 55.3	761.6 ± 41.5	0.005**	−0.317	0.002**
sdLDL-C	34.7 ± 2.4	28.1 ± 1.5	0.014*	−0.354	0.000**
HDL-P	35.1 ± 0.9	34.8 ± 0.9	0.851	−0.090	0.393
HDL2-C	10.1 ± 1.0	14.1 ± 1.1	0.010*	0.354	0.005**
ApoB	94.7 ± 3.5	84.4 ± 2.6	0.020*	−0.294	0.004**
Apo A1	130.±3.6	135.4 ± 3.3	0.354	0.039	0.708
Apo B/A ratio	0.73 ± 0.03	0.63 ± 0.02	0.006**	−0.291	0.005**

Data are presented as mean ± standard error, **, P < 0.01, *, P < 0.05.

Vit D3, 25-Hydroxy vitamin D; LDL-C, low-density lipoprotein cholesterol; HDL-C, High-density lipoprotein cholesterol; TG, total triglyceride; Non-HDL-C, non-high-density lipoprotein cholesterol; LDL-P, low-density lipoprotein particle; sLDL-P, Small dense low-density lipoprotein particle; sdLDL-C, small dense low-density lipoprotein cholesterol; HDL-P, High-density lipoprotein cholesterol particles; HDL2-C, High-density lipoprotein 2-cholesterol; ApoB, Apolipoprotein B; Apo A1, Apolipoprotein A1; ApoB/A ratio, Apolipoprotein B/Apolipoprotein A1 ratio.