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Review Article

Beyond the smiley face: applications of structural DNA nanotechnology

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Article: 1430976 | Received 07 Nov 2017, Accepted 17 Jan 2018, Published online: 25 Jan 2018

Figures & data

Figure 1. 3D DNA double-helix structure comprised phosphate backbones (purple) and hydrogen bonds between nitrogenous bases (yellow). Created using ANSYS software.

Figure 1. 3D DNA double-helix structure comprised phosphate backbones (purple) and hydrogen bonds between nitrogenous bases (yellow). Created using ANSYS software.

Figure 2. Design of the three-dimensional DNA origami: (a) Scaffold strands are depicted in grey, and staple strands are depicted in orange, white, and blue. Double helices run parallel to the Z-axis to form unrolled 2D target schema. Staple crossovers bridge layers together (semi-circular arcs), (b) cylindrical model of the intermediate, (c) 3D cylinder model of folded target shape; honeycomb arrangement is shown in cross sections (with i-iii indications). These helices are parallel to the x/y plane, (d) Atomistic model of (c). Reproduced with permission.

Figure 2. Design of the three-dimensional DNA origami: (a) Scaffold strands are depicted in grey, and staple strands are depicted in orange, white, and blue. Double helices run parallel to the Z-axis to form unrolled 2D target schema. Staple crossovers bridge layers together (semi-circular arcs), (b) cylindrical model of the intermediate, (c) 3D cylinder model of folded target shape; honeycomb arrangement is shown in cross sections (with i-iii indications). These helices are parallel to the x/y plane, (d) Atomistic model of (c). Reproduced with permission.

Figure 3. Three-dimensional DNA origami shapes: (a) monolith, (b) square nut, (c) railed bridge, (d) slotted cross, (e) stacked cross. Reproduced with permission.

Figure 3. Three-dimensional DNA origami shapes: (a) monolith, (b) square nut, (c) railed bridge, (d) slotted cross, (e) stacked cross. Reproduced with permission.

Figure 4. A DNA brick comprised four 8-nt domains; two of these domains are ‘head’ domains while the other two are ‘tail’ domains. Reproduced with permission.

Figure 4. A DNA brick comprised four 8-nt domains; two of these domains are ‘head’ domains while the other two are ‘tail’ domains. Reproduced with permission.