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Emerging Microbes & Infections Volume 12, 2023 - Issue 1
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Coronaviruses

Real-life effectiveness of COVID-19 vaccine during the Omicron variant-dominant pandemic: how many booster doses do we need?

Paskorn Sritipsukhoa Center of Excellence in Applied Epidemiology, Thammasat University, Pathumthani, Thailand;b Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Thana Khawcharoenporna Center of Excellence in Applied Epidemiology, Thammasat University, Pathumthani, Thailand;c Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumthani, ThailandCorrespondence[email protected]
View further author information
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Boonying Siribumrungwonga Center of Excellence in Applied Epidemiology, Thammasat University, Pathumthani, Thailand;d Department of Surgery, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Pansachee Damronglerdc Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Nuntra Suwantarate Department of Internal Medicine, Chulabhorn International College of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Araya Satdhabudhab Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Chanapai Chaiyakulsilb Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Phakatip Sinlapamongkolkulb Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Auchara Tangsathapornpongb Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Pornumpa Bunjoungmaneeb Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Sira Nanthapisala Center of Excellence in Applied Epidemiology, Thammasat University, Pathumthani, Thailand;b Department of Pediatrics, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Chamnan Tanprasertkula Center of Excellence in Applied Epidemiology, Thammasat University, Pathumthani, Thailand;f Department of Obstetrics & Gynecology, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
,
Naiyana Sritipsukhog Thammasat Postdoctoral Fellowship, Thammasat University, Pathumthani, ThailandView further author information
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Chatchai Mingmalairakd Department of Surgery, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Anucha Apisarnthanaraka Center of Excellence in Applied Epidemiology, Thammasat University, Pathumthani, Thailand;c Department of Internal Medicine, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
&
Pichaya Tantiyavarongh Department of Clinical Epidemiology, Faculty of Medicine, Thammasat University, Pathumthani, ThailandView further author information
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Article: 2174779 | Received 17 Oct 2022, Accepted 26 Jan 2023, Published online: 15 Feb 2023

Figures & data

Table 1. Characteristics of the study cohort, cases and controls.

Figure 1. Vaccine effectiveness (VE) for preventing Omicron variant-associated infection according to number of dose received by the study participants.

Note: The VE were adjusted for age, sex, education level, being unemployed, having any at-risk comorbidities and having persons with COVID-19 at home. I bars indicate 95% confidence intervals (CI).

Figure 1. Vaccine effectiveness (VE) for preventing Omicron variant-associated infection according to number of dose received by the study participants.Note: The VE were adjusted for age, sex, education level, being unemployed, having any at-risk comorbidities and having persons with COVID-19 at home. I bars indicate 95% confidence intervals (CI).

Figure 2. Vaccine effectiveness (VE) for preventing Omicron variant-associated moderate to critical diseases according to number of dose received by the study participants.

Note: The VE were adjusted for age, sex, education level, being unemployed, having any at-risk comorbidities and having persons with COVID-19 at home. I bars indicate 95% confidence intervals (CI). Cases were those with moderate to critical diseases and controls were those without COVID-19.

Figure 2. Vaccine effectiveness (VE) for preventing Omicron variant-associated moderate to critical diseases according to number of dose received by the study participants.Note: The VE were adjusted for age, sex, education level, being unemployed, having any at-risk comorbidities and having persons with COVID-19 at home. I bars indicate 95% confidence intervals (CI). Cases were those with moderate to critical diseases and controls were those without COVID-19.

Table 2. Vaccine effectiveness for preventing infection and severity of COVID-19 among various vaccine regimens.

Table 3. COVID-19 vaccination status of the study participants stratified according to diseases status and severity.

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