Figures & data
Table 1. Clinical history of red foxes, skunks and mink naturally infected with various HPAI H5N1 viruses.
Table 2. Amino acid substitution in the H5N1 viruses associated with adaptation to mesocarnivore species.
Bussey KA, Bousse TL, Desmet EA, et al. PB2 residue 271 plays a key role in enhanced polymerase activity of influenza A viruses in mammalian host cells. J Virol. 2010;84:4395–4406. Yamayoshi S, Yamada S, Fukuyama S, et al. Virulence-affecting amino acid changes in the PA protein of H7N9 influenza A viruses. J Virol. 2014;88:3127–3134. Yamayoshi S, Kiso M, Yasuhara A, et al. Enhanced replication of highly pathogenic influenza A(H7N9) virus in humans. Emerg Infect Dis. 2018;24:746–750. Gabriel G, Czudai-Matwich V, Klenk HD. Adaptive mutations in the H5N1 polymerase complex. Virus Res. 2013;178:53–62. Taft AS, Ozawa M, Fitch A, et al. Identification of mammalian-adapting mutations in the polymerase complex of an avian H5N1 influenza virus. Nat Commun. 2015;17(6):7491. Li J, Ishaq M, Prudence M, et al. Single mutation at the amino acid position 627 of PB2 that leads to increased virulence of an H5N1 avian influenza virus during adaptation in mice can be compensated by multiple mutations at other sites of PB2. Virus Res. 2009;144:123–129. Elgendy EM, Arai Y, Kawashita N, et al. Identification of polymerase gene mutations that affect viral replication in H5N1 influenza viruses isolated from Pigeons. J Gen Virol. 2017;98:6–17. Feng X, Wang Z, Shi J, et al. Glycine at position 622 in PB1 contributes to the virulence of H5N1 avian influenza virus in mice. J Virol. 2016;90:1872–1879. Gabriel G, Dauber B, Wolff T, et al. The viral polymerase mediates adaptation of an avian influenza virus to a mammalian host. Proc Natl Acad Sci. 2005;102:18590–18595. Gabriel G, Herwig A, Klenk HD. Interaction of polymerase subunit PB2 and NP with importin α1 Is a determinant of host range of influenza A virus. PLoS Pathog. 2008;4:e11.