Restricted CD4+ T cell receptor repertoire impairs cognitive function via alteration of Th2 cytokine levels

Figures & data

Figure 1. Proposed model of impaired cognitive function induced by alteration of Th2 cytokine levels. Mice with restricted CD4+ T cell receptor repertoire showed significant increased Th2 cytokine levels in peripheral and IL-4 in brain. Altered Th2 cytokine levels decrease the adult hippocampal neurogenesis as well as the cognitive function.