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Canadian Journal of Respiratory, Critical Care, and Sleep Medicine
Revue canadienne des soins respiratoires et critiques et de la médecine du sommeil
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Original Research

Early response to benralizumab in Canadian patients with severe eosinophilic asthma: Interim results from a prospective observational cohort

Stephen G. Noorduyna Department of Medical Affairs, AstraZeneca Canada, Mississauga, Ontario, Canada;b Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, CanadaView further author information
,
Sheena Kayaniyila Department of Medical Affairs, AstraZeneca Canada, Mississauga, Ontario, CanadaView further author information
,
Brett Lancastera Department of Medical Affairs, AstraZeneca Canada, Mississauga, Ontario, CanadaView further author information
,
Delbert Dorscheidc Center for Heart Lung Innovation, St. Paul ‘s Hospital, Vancouver, British Columbia, CanadaORCID Iconhttps://orcid.org/0000-0002-0680-0258View further author information
ORCID Icon,
Olga Tourind U-Breathe Clinic, Calgary, Alberta, CanadaView further author information
,
Brandie Walkere Health Research and Innovation Centre, University of Calgary, Calgary, Alberta, CanadaView further author information
,
Amin Thawerf Peak Medical Group, Red Deer, Alberta, CanadaView further author information
,
Warren Rameshg Edmonton Respiratory Consultants, Edmonton, Alberta, CanadaView further author information
,
Irfan Khanh North Bay Regional Health Centre, North Bay, Ontario, CanadaView further author information
,
Harold Kimi Division of Clinical Immunology and Allergy, Western University, London, Ontario, Canada;j Department of Medicine, McMaster University, Hamilton, Ontario, CanadaView further author information
,
Gordon Sussmank Gordon Sussman Clinical Research Inc, Toronto, Ontario, CanadaView further author information
,
Lawrence Mbuagbawb Department of Health Research Methods, Evidence, and Impact, McMaster University, Hamilton, Ontario, CanadaView further author information
&
Erika Penzl Division of Respirology, Critical Care and Sleep Medicine, University of Saskatchewan, Saskatoon, Saskatchewan, CanadaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-2610-8450View further author information
ORCID Icon show all
Received 11 Jan 2024, Accepted 28 Mar 2024, Published online: 23 Apr 2024

Figures & data

Figure 1. Study design & patient assessment timing. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item; AQLQ, Asthma Quality of Life Questionnaire; EQ-5D-5L, EuroQol 5 Dimension, 5-level; HCRU, Healthcare resource utilization; Med, Medication; PGI-C/S: Patients’ Global Impression of Change/Severity; SAE, Serious adverse event; TSQM-9, Treatment Satisfaction Questionnaire for Medication, Version 9.

Figure 1. Study design & patient assessment timing. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item; AQLQ, Asthma Quality of Life Questionnaire; EQ-5D-5L, EuroQol 5 Dimension, 5-level; HCRU, Healthcare resource utilization; Med, Medication; PGI-C/S: Patients’ Global Impression of Change/Severity; SAE, Serious adverse event; TSQM-9, Treatment Satisfaction Questionnaire for Medication, Version 9.

Table 1. Patient demographics in patients with baseline assessments.

Figure 2. Mean asthma control (ACQ-6) score and change in ACQ-6 score from baseline. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item.

Figure 2. Mean asthma control (ACQ-6) score and change in ACQ-6 score from baseline. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item.

Figure 3. Mean ACQ-6 scores, and change in ACQ-6 scores from baseline at each follow-up, by response at 24 weeks follow-up. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item. At 24 weeks, “Uncontrolled” asthma: ACQ-6 score ≥1.5; “partial control”: ACQ-6 score >0.75 and <1.5; “controlled” asthma: ACQ-6 score ≤0.75.

Figure 3. Mean ACQ-6 scores, and change in ACQ-6 scores from baseline at each follow-up, by response at 24 weeks follow-up. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item. At 24 weeks, “Uncontrolled” asthma: ACQ-6 score ≥1.5; “partial control”: ACQ-6 score >0.75 and <1.5; “controlled” asthma: ACQ-6 score ≤0.75.

Figure 4. (A) Mean asthma quality of life (AQLQ) scores, and change in AQLQ scores from baseline at each follow-up; (B) General quality of life (EQ-5D-5L utilities) and change from from baseline at each follow-up. Abbreviations: AQLQ, Asthma Quality of Life Questionnaire; EQ-5D-5L, EuroQol 5 Dimension, 5-level.

Figure 4. (A) Mean asthma quality of life (AQLQ) scores, and change in AQLQ scores from baseline at each follow-up; (B) General quality of life (EQ-5D-5L utilities) and change from from baseline at each follow-up. Abbreviations: AQLQ, Asthma Quality of Life Questionnaire; EQ-5D-5L, EuroQol 5 Dimension, 5-level.

Figure 5. Change from baseline in AQLQ over 24 weeks of treatment, stratified by ACQ-6 responder status at 24 weeks. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item; AQLQ, Asthma Quality of Life Questionnaire. At 24 weeks, “Uncontrolled” asthma: ACQ-6 ≥ 1.5; “partial control”: ACQ-6 > 0.75 and <1.5; “controlled” asthma: ACQ-6 ≤ 0.75.

Figure 5. Change from baseline in AQLQ over 24 weeks of treatment, stratified by ACQ-6 responder status at 24 weeks. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item; AQLQ, Asthma Quality of Life Questionnaire. At 24 weeks, “Uncontrolled” asthma: ACQ-6 ≥ 1.5; “partial control”: ACQ-6 > 0.75 and <1.5; “controlled” asthma: ACQ-6 ≤ 0.75.

Figure 6. Change from baseline in EQ-5D-5L utilities over 24 weeks of treatment, stratified by ACQ-6 responder status at 24 weeks. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item; EQ-5D-5L, EuroQol 5 Dimension, 5-level. At 24 weeks, “Uncontrolled” asthma: ACQ-6 ≥ 1.5; “partial control”: ACQ-6 > 0.75 and <1.5; “controlled” asthma: ACQ-6 ≤ 0.75.

Figure 6. Change from baseline in EQ-5D-5L utilities over 24 weeks of treatment, stratified by ACQ-6 responder status at 24 weeks. Abbreviations: ACQ-6, Asthma Control Questionnaire, 6 Item; EQ-5D-5L, EuroQol 5 Dimension, 5-level. At 24 weeks, “Uncontrolled” asthma: ACQ-6 ≥ 1.5; “partial control”: ACQ-6 > 0.75 and <1.5; “controlled” asthma: ACQ-6 ≤ 0.75.

Figure 7. Change from baseline in work productivity and activity impairment. Abbreviations: WPAI, Work Productivity and Activity Impairment Questionnaire.

Figure 7. Change from baseline in work productivity and activity impairment. Abbreviations: WPAI, Work Productivity and Activity Impairment Questionnaire.
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