Early effects of selective serotonin reuptake inhibitors (SSRIs) on cornea and lens density in patients with depression

Figures & data

Figure 1. LD (3D) measurements; a 1 mm (vertical) × 2 mm (horizontal) rectangle was drawn.

Figure 2. CD measurements were manually performed on the apex of the cornea.

Figure 3. Overall effect of SSRIs on CD, LD and IOP.

Table 1. Results of repeated measures ANOVA for Sertraline, 50 mg/daily, on ocular parameters.

Parameter	Drug	Mean	SD	F (P value)
ACD Baseline	Sertralin 50 mg	2.8450	0.3026	* 0.977 (0.371)
ACD 1 week	Sertralin 50 mg	2.8370	0.3024
ACD 1 month	Sertralin 50 mg	2.8425	0.3024
ACD 3 month	Sertralin 50 mg	2.8415	0.2985
ACV Baseline	Sertralin 50 mg	167.5500	31.6385	* 1.585 (0.221)
ACV 1 week	Sertralin 50 mg	168.5500	30.9557
ACV 1 month	Sertralin 50 mg	168.3500	30.6014
ACV 3 month	Sertralin 50 mg	168.8000	29.9061
CCT Baseline	Sertralin 50 mg	541.3000	30.8393	* 1.242 (0.300)
CCT 1 week	Sertralin 50 mg	542.3500	30.8583
CCT 1 month	Sertralin 50 mg	542.2500	30.7723
CCT 3 month	Sertralin 50 mg	542.2500	29.4859
CD Baseline	Sertralin 50 mg	12.4950	0.7344	* 0.801 (0.433)
CD 1 week	Sertralin 50 mg	12.4350	0.6491
CD 1 month	Sertralin 50 mg	12.4100	0.6950
CD 3 month	Sertralin 50 mg	12.4450	0.5652
CV Baseline	Sertralin 50 mg	59.7150	2.6837	* 0.491 (0.605)
CV 1 week	Sertralin 50 mg	59.6900	2.6610
CV 1 month	Sertralin 50 mg	59.7300	2.6958
CV 3 month	Sertralin 50 mg	59.7450	2.6867
IOP Baseline	Sertralin 50 mg	15.8000	2.8022	* 7.201 (0.002)
IOP 1 week	Sertralin 50 mg	15.6500	2.6011
IOP 1 month	Sertralin 50 mg	15.2000	2.3753
IOP 3 month	Sertralin 50 mg	14.9000	1.9166
LD Baseline	Sertralin 50 mg	7.5730	0.4566	* 2.093 (0.146)
LD 1 week	Sertralin 50 mg	7.4900	0.4290
LD 1 month	Sertralin 50 mg	7.5650	0.4171
LD 3 month	Sertralin 50 mg	7.5900	0.3537

IOP; intraocular pressure, ACD; anterior chamber depth, CV; corneal volume, ACV; anterior chamber volume, CD; corneal density, LD; lens density, CCT; central corneal thickness. *Greenhouse-Geisser test was used, P value of <0.05 was considered as significant.

Table 2. Results of repeated measures ANOVA for Escitalopram, 10 mg/daily, on ocular parameters.

Parameter	Drug	Mean	SD	F (P value)
ACD Baseline	Escitalopram 10 mg	3.0405	0.3789	* 0.572 (0.589)
ACD 1 week	Escitalopram 10 mg	3.0345	0.3798
ACD 1 month	Escitalopram 10 mg	3.0391	0.3843
ACD 3 month	Escitalopram 10 mg	3.0391	0.3788
ACV Baseline	Escitalopram 10 mg	173.5455	33.8620	* 1.338 (0.273)
ACV 1 week	Escitalopram 10 mg	173.0455	33.8870
ACV 1 month	Escitalopram 10 mg	173.9091	33.8571
ACV 3 month	Escitalopram 10 mg	173.8636	33.3670
CCT Baseline	Escitalopram 10 mg	523.0909	27.3911	** 0.642 (0.553)
CCT 1 week	Escitalopram 10 mg	523.3182	27.7478
CCT 1 month	Escitalopram 10 mg	523.1364	27.3466
CCT 3 month	Escitalopram 10 mg	524.0000	25.7589
CD Baseline	Escitalopram 10 mg	12.5045	0.9068	* 0.316 (0.717)
CD 1 week	Escitalopram 10 mg	12.5182	0.7762
CD 1 month	Escitalopram 10 mg	12.5318	0.8155
CD 3 month	Escitalopram 10 mg	12.5591	0.7601
CV Baseline	Escitalopram 10 mg	58.6864	1.5606	* 0.719 (0.471)
CV 1 week	Escitalopram 10 mg	58.6182	1.5570
CV 1 month	Escitalopram 10 mg	58.6455	1.5607
CV 3 month	Escitalopram 10 mg	58.6227	1.5893
IOP Baseline	Escitalopram 10 mg	15.2727	2.3539	* 12.424 (0.000)
IOP 1 week	Escitalopram 10 mg	15.3636	2.3613
IOP 1 month	Escitalopram 10 mg	15.0000	2.3704
IOP 3 month	Escitalopram 10 mg	14.5000	2.1984
LD Baseline	Escitalopram 10 mg	7.5955	0.4380	* 1.804 (0.177)
LD 1 week	Escitalopram 10 mg	7.5591	0.4521
LD 1 month	Escitalopram 10 mg	7.6045	0.4775
LD 3 month	Escitalopram 10 mg	7.6591	0.4656

IOP; intraocular pressure, ACD; anterior chamber depth, CV; corneal volume, ACV; anterior chamber volume, CD; corneal density, LD; lens density, CCT; central corneal thickness.

*Greenhouse-Geisser test was used, P value of <0.05 was considered as significant.

Table 3. Results of repeated measures ANOVA for Fluoxetine, 20 mg/daily, on ocular parameters.

Parameter	Drug	Mean	SD	F (P value)
ACD Baseline	Fluoksetin 50 mg	2.9175	0.2930	** 5.642 (0.002)
ACD 1 week	Fluoksetin 50 mg	2.9110	0.2951
ACD 1 month	Fluoksetin 50 mg	2.9170	0.2920
ACD 3 month	Fluoksetin 50 mg	2.9260	0.2858
ACV Baseline	Fluoksetin 50 mg	165.8500	39.4438	** 0.440 (0.725)
ACV 1 week	Fluoksetin 50 mg	165.4000	39.1319
ACV 1 month	Fluoksetin 50 mg	165.5000	38.7712
ACV 3 month	Fluoksetin 50 mg	165.3000	39.4849
CCT Baseline	Fluoksetin 50 mg	561.5500	29.8531	** 1.442 (0.240)
CCT 1 week	Fluoksetin 50 mg	561.6000	30.0270
CCT 1 month	Fluoksetin 50 mg	562.3500	29.5746
CCT 3 month	Fluoksetin 50 mg	560.9500	28.6622
CD Baseline	Fluoksetin 50 mg	12.4550	0.6969	** 3.111 (0.094)
CD 1 week	Fluoksetin 50 mg	12.4500	0.6939
CD 1 month	Fluoksetin 50 mg	12.4150	0.6998
CD 3 month	Fluoksetin 50 mg	12.3300	0.7320
CV Baseline	Fluoksetin 50 mg	62.6050	2.9523	* 0.256 (0.670)
CV 1 week	Fluoksetin 50 mg	62.5650	2.9487
CV 1 month	Fluoksetin 50 mg	62.5750	2.9282
CV 3 month	Fluoksetin 50 mg	62.6050	2.9281
IOP Baseline	Fluoksetin 50 mg	14.1500	1.3484	* 0.286 (0.660)
IOP 1 week	Fluoksetin 50 mg	14.1500	1.3869
IOP 1 month	Fluoksetin 50 mg	14.0500	1.1909
IOP 3 month	Fluoksetin 50 mg	14.0500	1.2763
LD Baseline	Fluoksetin 50 mg	7.5550	0.4781	** 0.588 (0.626)
LD 1 week	Fluoksetin 50 mg	7.6000	0.4834
LD 1 month	Fluoksetin 50 mg	7.5550	0.4454
LD 3 month	Fluoksetin 50 mg	7.5550	0.4097

IOP; intraocular pressure, ACD; anterior chamber depth, CV; corneal volume, ACV; anterior chamber volume, CD; corneal density, LD; lens density, CCT; central corneal thickness. **Sphericity Asuumed test, P value of <0.05 was considered as significant.