Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ_(1–42)-infused rat model of Alzheimer's disease

Birsen ElibolDepartment of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, TurkeyCorrespondence[email protected]

https://orcid.org/0000-0002-9462-0862 View further author information

Sule Terzioglu-UsakDepartment of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, Turkey

https://orcid.org/0000-0002-4594-2697 View further author information

Merve BekerDepartment of Medical Biology, Faculty of Medicine, Bezmialem Vakif University, Istanbul, TurkeyView further author information

Cigdem SahbazDepartment of Psychiatry, Faculty of Medicine, Bezmialem Vakif University, Istanbul, TurkeyView further author information

Figures & data

Figure 1. Mean swimlatency calculated on the first and fourth day of the acquisition phase of Morris water maze test for all groups. Error bars denote SEM. The degree of significance is denoted as * for p ≤ 0.05.

Figure 2. The concentrations of selected inflammatory markers (A) IFN-γ (B) IL-1α (C) IL-1β (D) TNF-α.which were measured by Magnetic Luminex system for all groups. Error bars denote SEM. The degree of significance is denoted as * for p ≤ 0.05.

Table 1. The results of Pearson's correlation of the levels of IFN-γ, IL-1α, IL-1β and TNF-α with each other among sham, Aβ_(1–42) and Aβ_(1–42) + TQ groups.

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Figure 3. Representative pictures and relative amounts of (A) DCX to beta tubulin (B) MAP-2 to beta tubulin, and (C) PARP 89/116protein expressions analyzed by Western blot for all groups. Error bars indicate SEM. The degree of significance is denoted as * for p ≤ 0.05, ** for p ≤ 0.01, and *** for p ≤ 0.001.

Table 2. The results of Pearson's correlation of the levels of inflammatory markers with DCX, MAP2 and PARP in the sham, Aβ_(1–42) and Aβ_(1–42) + TQ groups.

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Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ_(1–42)-infused rat model of Alzheimer's disease

Table 1. The results of Pearson's correlation of the levels of IFN-γ, IL-1α, IL-1β and TNF-α with each other among sham, Aβ_(1–42) and Aβ_(1–42) + TQ groups.

Table 2. The results of Pearson's correlation of the levels of inflammatory markers with DCX, MAP2 and PARP in the sham, Aβ_(1–42) and Aβ_(1–42) + TQ groups.

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Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ(1–42)-infused rat model of Alzheimer's disease

Figures & data

Table 1. The results of Pearson's correlation of the levels of IFN-γ, IL-1α, IL-1β and TNF-α with each other among sham, Aβ(1–42) and Aβ(1–42) + TQ groups.

Table 2. The results of Pearson's correlation of the levels of inflammatory markers with DCX, MAP2 and PARP in the sham, Aβ(1–42) and Aβ(1–42) + TQ groups.

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Thymoquinone (TQ) demonstrates its neuroprotective effect via an anti-inflammatory action on the Aβ_(1–42)-infused rat model of Alzheimer's disease

Table 1. The results of Pearson's correlation of the levels of IFN-γ, IL-1α, IL-1β and TNF-α with each other among sham, Aβ_(1–42) and Aβ_(1–42) + TQ groups.

Table 2. The results of Pearson's correlation of the levels of inflammatory markers with DCX, MAP2 and PARP in the sham, Aβ_(1–42) and Aβ_(1–42) + TQ groups.