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Autophagy Reports Volume 2, 2023 - Issue 1
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Autophagic Punctum

The ubiquitin E3 ligase TRIM27 emerges as a new player in mitophagy

Anne Kristin McLaren Bergea Department of Medical Biology, Autophagy Research Group, University of Tromsø–The Arctic University of Norway, NorwayView further author information
,
Juncal Garcia-Garciab Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, NorwayView further author information
,
Eva Sjøttema Department of Medical Biology, Autophagy Research Group, University of Tromsø–The Arctic University of Norway, NorwayView further author information
&
Hallvard Lauritz Olsvika Department of Medical Biology, Autophagy Research Group, University of Tromsø–The Arctic University of Norway, NorwayCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-3489-7461View further author information
ORCID Icon
Article: 2164089 | Received 12 Dec 2022, Accepted 23 Dec 2022, Published online: 05 Jan 2023

Figures & data

Figure 1. TRIM27-TBK1-SQSTM1/p62 complex assembly and induction of mitophagy. TRIM27 close to mitochondria recruit TBK1, leading to its activation and stabilization. Active TBK1 phosphorylates SQSTM1/p62, enhancing the affinity of SQSTM1/p62 for ubiquitinated substrates on the mitochondrial outer membrane leading to mitochondrial clustering and mitophagy.

Figure 1. TRIM27-TBK1-SQSTM1/p62 complex assembly and induction of mitophagy. TRIM27 close to mitochondria recruit TBK1, leading to its activation and stabilization. Active TBK1 phosphorylates SQSTM1/p62, enhancing the affinity of SQSTM1/p62 for ubiquitinated substrates on the mitochondrial outer membrane leading to mitochondrial clustering and mitophagy.
 

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