https://orcid.org/0000-0002-6400-0945
Figures & data
Figure 1. Schematic of consequences of NGLY1 function. Terminally misfolded proteins are exported to the cytosol from the ER lumen. (a) In the presence of NGLY1, glycans are cleaved from the exported proteins and the protein material targeted for degradation via the proteasome. (b) Autophagy induction is observed upon the inhibition of NGLY1. Figure 1 was partly generated using Servier Medical Art, provided by Servier, licensed under a Creative Commons Attribution 3.0 unported license https://creativecommons.org/licenses/by/3.0/
