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Autophagy Reports Volume 2, 2023 - Issue 1
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Autophagic punctum

Discovery of small-molecule inhibitors for the protein-protein interactions involving ATG5

Honggang XiangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai201203, People’s Republic of ChinaView further author information
&
Renxiao WangDepartment of Medicinal Chemistry, School of Pharmacy, Fudan University, 826 Zhangheng Road, Shanghai201203, People’s Republic of ChinaCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-0485-0259View further author information
ORCID Icon
Article: 2215617 | Received 05 May 2023, Accepted 15 May 2023, Published online: 27 May 2023

Figures & data

Figure 1. The ATG12–ATG5 conjugate interacts with ATG16L1 to form a ternary complex, which is responsible for ATG8/LC3 lipidation. T1742 is a small-molecule compound that blocks the ATG5-ATG16L1/TECAIR interactions at a low micromolar range (IC50 = 1~2 μM) and exhibits a dose-dependent impact on the LC3B-II level in living cells.

Figure 1. The ATG12–ATG5 conjugate interacts with ATG16L1 to form a ternary complex, which is responsible for ATG8/LC3 lipidation. T1742 is a small-molecule compound that blocks the ATG5-ATG16L1/TECAIR interactions at a low micromolar range (IC50 = 1~2 μM) and exhibits a dose-dependent impact on the LC3B-II level in living cells.
 

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