https://orcid.org/0000-0003-1120-444X
Figures & data
Figure 1. Ire1 acts as a lid to regulate proteostasis response during chronic stress in yeast cells. In the resting stage, Ire1 activates the UPR upon accumulation of misfolded mutant huntingtin (NT-103Q). We show that in the absence of Ire1, compensatory mechanisms such as autophagy and proteasomal function are upregulated upon prolonged stress and reduce aggregation of NT-103Q.
