https://orcid.org/0000-0001-6777-4498
Figures & data
Figure 1. Schema of the contributions of IDRs in the control of CLEC16A-RNF41-USP8 complex assembly. Stability of the CLEC16A-RNF41-USP8 complex is essential for optimal mitophagy. The CLEC16A C-terminal IDR increases CLEC16A stability by preventing degradative self-ubiquitination. CLEC16A stabilizes RNF41 via non-degradative ubiquitination, while RNF41 ubiquitinates and destabilizes CLEC16A by modifying the CLEC16A internal IDR. USP8 and RNF41 also participate in reciprocal cross-regulation. Overexpression of CLEC16A increases USP8 expression, yet the underlying mechanisms of this and the potential importance of the putative USP8 IDR in mitophagy remain unknown.
