https://orcid.org/0000-0003-2285-2282
Figures & data
Figure 1. Possible role of the yeast dynamin-like GTPase Vps1 in Atg9 trafficking during autophagy. Vps1 directly or indirectly, via one or more adaptors, interacts with Atg9 at Atg9 reservoirs, which are derived from the Golgi apparatus. Vps1 mediates Atg9 transport from the Atg9 reservoirs to the PAS, although a role in sorting from the Golgi cannot be excluded. At the PAS, Atg9 provides the seed membrane to form the phagophore, but it is also playing a key role in recruiting part of the Atg machinery and rearranges lipids on the phagophore membrane to assist in expansion. Once the autophagosome is completed, Atg9 is recycled from the autophagosomal membrane or the vacuole upon fusion of the autophagosome with this organelle. It is unclear if this retrograde transport brings Atg9 back to the Atg9 reservoirs or to the Golgi, from where it returns to the reservoirs.
