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Autophagic Punctum

Orchestration of autophagosome fusion by STRIPAK complex components in muscle tissue

ORCID Icon & ORCID Icon
Article: 2260670 | Received 25 Aug 2023, Accepted 14 Sep 2023, Published online: 27 Sep 2023

Figures & data

Figure 1. Model depicting possible degradation routes for Strip-mediated autophagosome turnover during autophagy in D. melanogaster muscles. Phagophores expand into double-membrane autophagosomes and these complete autophagosomes can directly fuse with lysosomes (solid arrows). Endosomes can also fuse with autophagosomes to produce an intermediate amphisome structure before fusion with lysosomes and subsequent cargo degradation (dotted arrows). Created with Biorender.com

Figure 1. Model depicting possible degradation routes for Strip-mediated autophagosome turnover during autophagy in D. melanogaster muscles. Phagophores expand into double-membrane autophagosomes and these complete autophagosomes can directly fuse with lysosomes (solid arrows). Endosomes can also fuse with autophagosomes to produce an intermediate amphisome structure before fusion with lysosomes and subsequent cargo degradation (dotted arrows). Created with Biorender.com