Figures & data
Figure 1. In oral cancer cells, MTFP1 plays a crucial role in mitochondrial fission and mitochondrial morphology maintenance. Upon exposure to anticancer drugs, MTFP1 interacts with MAP1LC3B, promoting mitophagy to eliminate dysfunctional mitochondria through PINK1/PRKN-dependent mitophagy. MTFP1-dependent mitophagy is cytoprotective and provides survival benefits to cancer cells. The mutant LIR MTFP1 can not interact with MAP1LC3B to induce mitophagy, leading to cell death during anticancer treatment.
