AeiA, an Atg8-interacting protein in Aspergillus oryzae, promotes peroxisome degradation by pexophagy

Figures & data

Figure 1. A speculative model for the action of AeiA in pexophagy (A) Schematic representation of AeiA structures. AeiA interacts with AoAtg8 via AIM2 and AIM3 [1]. MTS consists of the amino acid sequence A-R-L. (B) Putative role of AeiA in pexophagy. AeiA associates to peroxisomes by binding via its MTS the PTS receptor AoPex5, which form a complex with the peroxisomal membrane protein AoPex14. In addition, AeiA might be recognized by an unknown protein present on peroxisomal membrane, because AeiA appeared to be transported to the lumen of peroxisomes [1]. Under pexophagy inducing condition such as growth in oleic acid-containing medium, AeiA interacts with AoAtg8 pool present on the phagophore to promote sequestration of peroxisomes within autophagosomes.

Nishio J, Takahashi Y, Kasahara M, Takeda Y, Kikuma T. AeiA is a novel autophagy-related protein that promotes peroxisome degradation by pexophagy in Aspergillus oryzae. FEBS Lett. 2023; 597: 608–4.

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