Figures & data
Figure 1. The LIPA system is based on the fusion of the photoreceptor CRYolig2, which undergoes robust clustering upon stimulation with blue light. Fusion of CRYolig2 with α-syn and mCherry allows to control and visualize LIPA-α-syn aggregation. LIPA-α-syn aggregates contact with the cytosolic face of mitochondria in a kiss-and-run manner, leading to mitochondrial dysfunction. This causes a translocation of cardiolipin to the OMM, triggering mitophagy.
