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Autophagic Punctum

Combining doxorubicin and miR-218-5p: a new strategy to fight breast cancer?

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Article: 2342129 | Received 28 Mar 2024, Accepted 08 Apr 2024, Published online: 25 Apr 2024

Figures & data

Figure 1. Co-administration of miR-218-5p improves the efficacy of the chemotherapeutic drug DXR in stem and non-stem breast cancer cells. DXR treatment induces production of ROS and the mitophagic pathway mediated by PINK1 and PARKIN in BC cells. miR-218-5p, by inhibiting this mitophagy through PARKIN depletion, favours cytotoxicity of DXR. Created with BioRender.com.

Figure 1. Co-administration of miR-218-5p improves the efficacy of the chemotherapeutic drug DXR in stem and non-stem breast cancer cells. DXR treatment induces production of ROS and the mitophagic pathway mediated by PINK1 and PARKIN in BC cells. miR-218-5p, by inhibiting this mitophagy through PARKIN depletion, favours cytotoxicity of DXR. Created with BioRender.com.