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Clinical, Cosmetic and Investigational Dermatology Volume 17, 2024 - Issue
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CASE REPORT

Surgical Treatment of Multiple Large Tuberous and Tendinous Xanthoma Secondary to Familial Hypercholesterolaemia: A Case Report

Haonan GuanDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of ChinaORCID Iconhttps://orcid.org/0000-0002-4832-5758View further author information
ORCID Icon,
Guoyou ZhangDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
,
Qiqi LiDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
,
Jie LianDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
,
Zhaoyang DongDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
,
Lian ZhuDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of ChinaView further author information
&
Kaiyan XiaoDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiaotong University School of Medicine, Shanghai, People’s Republic of ChinaCorrespondence[email protected]
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Pages 961-966 | Received 30 Oct 2023, Accepted 14 Mar 2024, Published online: 29 Apr 2024

Figures & data

Figure 1 Multiple subcutaneous lesions over different locations. (A and B) lesions in both elbows. (C) lesions in both knees. (D) lesions in buttocks. (E) lesions in Achilles tendons. (F) lesions over proximal interphalangeal joints.

Figure 1 Multiple subcutaneous lesions over different locations. (A and B) lesions in both elbows. (C) lesions in both knees. (D) lesions in buttocks. (E) lesions in Achilles tendons. (F) lesions over proximal interphalangeal joints.

Figure 2 MRI imaging of xanthomas masses on left (A and B) and right (C and D) elbows. The masses revealed low signal intensity on T1-weighted images and low-high mixed signal intensity on T2-weighted images.

Figure 2 MRI imaging of xanthomas masses on left (A and B) and right (C and D) elbows. The masses revealed low signal intensity on T1-weighted images and low-high mixed signal intensity on T2-weighted images.

Figure 3 Intraoperative photograph of the lesions. (A and B) Resected xanthomas. (C) The sectional view of the xanthomas.

Figure 3 Intraoperative photograph of the lesions. (A and B) Resected xanthomas. (C) The sectional view of the xanthomas.

Figure 4 Pathological pictures of the lesion. (A) Hematoxylin/eosin analysis showed infiltration of foamy cells and scattered giant cells (x200). CD68-immunostaining (B), Ki67- immunostaining (C) and TFE3- immunostaining (D) of the xanthomas presented positive (x200).

Figure 4 Pathological pictures of the lesion. (A) Hematoxylin/eosin analysis showed infiltration of foamy cells and scattered giant cells (x200). CD68-immunostaining (B), Ki67- immunostaining (C) and TFE3- immunostaining (D) of the xanthomas presented positive (x200).

Figure 5 Status of the incisions two days after the operation. (A and B) elbows. (C) buttocks. (D) knees.

Figure 5 Status of the incisions two days after the operation. (A and B) elbows. (C) buttocks. (D) knees.

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