A Frequent Diagnostic Pitfall: Dermatological Clinical Features and Pathological Results in Diagnosing Pagetoid Squamous Cell Carcinoma in situ (Case Series)

Figures & data

Figure 1 HE staining: A large number of nested Paget-like cells were found throughout the epidermis. The cytoplasm of tumor cells is rich, transparent and vacuolar. The basement membrane was intact, and a large number of lymph and plasma cells were infiltrated at the epidermal dermal junction. (A) Case1 (200X), (B) Case2 (200X), (C) Case3 (200X).

Figure 2 Immunohistochemical stain: We highlight the immunohistochemical staining of case 3. CK5/6 was positive for intact membrane, P63 was positive for nucleation, and CEA was negative. (A) CK5/6+ (200X), (B) P63+ (200X), (C) CEA- (200X).

Table 1 Summary of Information and Immunohistochemical Stains of Patients with Pagetoid Squamous Cell Carcinoma

	Age	Gender	Site	CK5/6	P63	CK7	P16	CEA	S–100	HMB45	PAS	Ref.
Case1	70 years	Male	Left thigh	+	+	/	+	–	–	–	/
Case2	83 years	Male	Left back	+	+	/	+	–	–	–	/
Case3	88 years	Male	Left leg	+	+	Focal+	+	–	–	–	/
Lee (2021)	85 years	Female	Left cheek	+	+	Focal+	/	/	/	–	/	[13]
Wu (2019)	52 years	Female	Left thorax	/	/	/	/	/	/	/	/	[14]
Lee (2018)	76 years	Male	Left leg	+	+	±	/	/	/	/	/	[15]
Wang (2016)	87 years	Female	Right nipple	/	/	–	/	–	–	/	/	[16]
Gao (2011)	84 years	Male	Abdomen	/	/	–	/	–	/	/	–	[17]
Wang (2010)	40 years	Male	Right toe	/	/	/	/	–	–	/	–	[18]
Han (2009)	57 years	Male	Left thorax	/	/	/	/	/	/	/	/	[19]
Xu (2009)	70 years	Female	Left shoulder	/	/	/	/	/	/	/	–	[20]
Cong (2008)	84 years	Male	Right anterior wall	/	/	/	/	/	/	/	/	[21]
Lao (2006)	45 years	Male	Left leg	/	/	/	/	–	/	/	/	[22]
Jin (2004)	85 years	Female	Anterior left ear	/	/	/	/	–	/	/	–	[23]

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