Correlation Between IL-8, C-Reactive Proteins (CRP) and Neutrophil to Lymphocyte Ratio (NLR) as Predictor of Mortality in COVID-19 Patients with Diabetes Mellitus Comorbidity

Figures & data

Table 1 Laboratory Parameters Between DM and Non-DM COVID-19 Patients

Variable	Non-DM	DM	P-value*
	Median (Min:Max)	Median (Min:Max)
Hemoglobin (g/dL)	13.1 (3.20–18.70)	13.85 (2.70–17.30)	0.363
Leukocytes (10^3/mm^3)	8.74 (2.23–28.98)	9.76 (3.04–32.98)	0.082
Platelets (/mm3)	216,500 (27,000–482,000)	247,000 (78,000–818,000)	0.459
Neutrophil-to-Lymphocyte Ratio (NLR)	6.60 (1.00–48.40)	8.59 (1.07–45.45)	0.183
Random Blood Glucose (RBG) (mg/dL)	107.5 (76.0–349.0)	297.5 (101.0–796.0)	0.000
C-Reactive Protein (CRP) (mg/dL)	2.24 (0.13–24.19)	9.05 (0.70–37.51)	0.000
Interleukin-8 (IL-8) (pg/mL)	108.3 (19.6–1250.18)	128.7 (24.9–1236.89)	0.132

Note: *Mann–Whitney difference test results, significant differences are in bold.

Table 2 Laboratory Parameters in COVID-19 Patients with DM Comorbidity Based on Mortality

Characteristics	Survivors (Min:Max)	Non Survivor (Min:Max)	P-value*
Hemoglobin (g/dL)	14.4 (7.30–17.30)	13.7 (2.70–17.20)	0.180
Leukocytes (10^3/mm^3)	7.68 (3.04–32.98)	14.08 (4.36–29.76)	0.029
Platelets (/mm^3)	256,500 (137,000–818,000)	219,500 (78,000–553,000)	0.726
Neutrophil-to-Lymphocyte Ratio (NLR)	6.88 (1.07–15.80)	9.73 (4.82–45.45)	0.048
Random Blood Glucose (RBG)(mg/dL)	261.5 (141.0–612.0)	324.5 (101.0–796.0)	0.200
C-Reactive Protein (CRP) (mg/dL)	4.11 (0.70–16.21)	16.66 (1.15–37.51)	0.000
Interleukin-8 (IL-8) (pg/mL)	59.21 (24.90–119.18)	392.18 (76.27–1236.89)	0.000

Note: *Mann–Whitney difference test results, significant differences are in bold.

Table 3 The Result of Pearson Correlation Between IL-8, NLR and CRP with Mortality

	Mortality (All COVID-19 Patients)		Mortality (Only COVID-19 with DM)
	r	p	r	p
IL-8	0.63	0.00	0.54	0.00
CRP	0.70	0.00	0.59	0.00
NLR	0.58	0.00	0.45	0.03
DM	0.44	0.00	–	–