The role of the human Duffy antigen receptor for chemokines in malaria susceptibility: current opinions and future treatment prospects

Figures & data

Figure 1 A model for DBP–DARC interaction during invasion.

Notes: DBP binds to DARC via a model of receptor-mediated ligand dimerization. Dimerization of DBP is induced upon receptor binding and drives recognition of DARC. An initial binding event is followed by receptor-induced dimerization (DBPII–DARC heterotrimer). This brings a second DBPII molecule in close proximity to a second DARC ectodomain in the DARC homodimer. A second binding event creates the DBPII–DARC heterotetramer. DBPII molecules: green and yellow. DARC19–30 molecules: purple and blue. A schematic for the stepwise assembly is shown at the bottom. Closed circle: bound DBPII and open circle: unbound DBPII. Adapted from Batchelor JD, Malpede BM, Omattage NS, DeKoster GT, Henzler-Wildman KA, Tolia NH. Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC. PLoS Pathog. 2014;10(1):e1003869.⁸³

Abbreviations: DBP, Duffy binding protein; DARC, Duffy antigen receptor for chemokine; P. vivax, Plasmodium vivax.

Batchelor JD, Malpede BM, Omattage NS, DeKoster GT, Henzler-Wildman KA, Tolia NH. Red blood cell invasion by Plasmodium vivax: structural basis for DBP engagement of DARC. PLoS Pathog. 2014;10(1):e1003869.

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