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Original Research

Multistate models on pleural effusion after allogeneic hematopoietic stem cell transplantation

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Pages 15-26 | Published online: 15 Apr 2017

Figures & data

Figure 1 Multistate models with single (A), independent (B), and cross-related (C, D) outcomes.

Notes: The traditional Cox proportional hazard model for the patients with HSCT for a single outcome is in (A), (B) is the competing risk model for the patients with HSCT for independent outcomes, the multistate model for the patients with HSCT is in (C) and (D) is the extended multistate model. Numbers in parentheses represent the number of patients who stayed in the corresponding state or underwent corresponding transition.
Abbreviations: GVHD, graft-versus-host disease; HSCT, hematopoietic stem cell transplantation; PE, pleural effusion; Tx, one initial state.
Figure 1 Multistate models with single (A), independent (B), and cross-related (C, D) outcomes.

Table 1 Hazard ratios with standard errors, confidence intervals, and p-values for the Markov proportional regression model of the significant covariates at a 5% significance level

Figure 2 Nonparametric estimates of the stacked transition probabilities at time 0 year (A), 0.5 year (B), 1 year (C), and 1.5 years (D) after the transplantation.

Abbreviations: GVHD, graft-versus-host disease; PE, pleural effusion; Tx, one initial state.
Figure 2 Nonparametric estimates of the stacked transition probabilities at time 0 year (A), 0.5 year (B), 1 year (C), and 1.5 years (D) after the transplantation.

Figure 3 Nonparametric estimates of the stacked transition probabilities at time 0 year (A), 0.5 year (B), 1 year (C), and 1.5 years (D) after the transplantation. Starting state is PE.

Abbreviations: GVHD, graft-versus-host disease; PE, pleural effusion.
Figure 3 Nonparametric estimates of the stacked transition probabilities at time 0 year (A), 0.5 year (B), 1 year (C), and 1.5 years (D) after the transplantation. Starting state is PE.

Figure 4 Nonparametric estimates of the stacked transition probabilities at time 0 year (A), 0.5 year (B), 1 year (C), and 1.5 years (D) after the transplantation. Starting state is GVHD.

Abbreviations: GVHD, graft-versus-host disease; PE, pleural effusion.
Figure 4 Nonparametric estimates of the stacked transition probabilities at time 0 year (A), 0.5 year (B), 1 year (C), and 1.5 years (D) after the transplantation. Starting state is GVHD.

Figure 5 The probabilities of being in different states for HLA 8/8 allele match patient (A) and intermediate disease risk index patient (B).

Abbreviations: GVHD, graft-versus-host disease; PE, pleural effusion; Tx, one initial state.
Figure 5 The probabilities of being in different states for HLA 8/8 allele match patient (A) and intermediate disease risk index patient (B).

Figure 6 Comparison of the cumulative death hazard transition for each state.

Abbreviations: GVHD, graft-versus-host disease; PE, pleural effusion; Tx, one initial state.
Figure 6 Comparison of the cumulative death hazard transition for each state.

Table S1 Predicted transition probabilities at time (a) 0 year, (b) 0.5 year, (c) 1 year, and (d) 1.5 years after the transplantation

Table S2 Predicted transition probabilities at time (a) 0 year, (b) 0.5 years, (c) 1 year, and (d) 1.5 years after the transplantation (starting state is PE)

Table S3 Predicted transition probabilities at time (a) 0 year, (b) 0.5 year, (c) 1 year, and (d) 1.5 years after the transplantation (starting state is GVHD)