Advanced search
Publication Cover
Pragmatic and Observational Research Volume 15, 2024 - Issue
Submit an article Journal homepage
162
Views
0
CrossRef citations to date
0
Altmetric
ORIGINAL RESEARCH

Drug Repurposing in Crohn’s Disease Using Danish Real-World Data

Saeed Shakibfar1 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DenmarkCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0001-8399-0318View further author information
ORCID Icon,
Kristine H Allin2 Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University, Copenhagen, DenmarkORCID Iconhttps://orcid.org/0000-0002-6880-5759View further author information
ORCID Icon,
Tine Jess2 Center for Molecular Prediction of Inflammatory Bowel Disease (PREDICT), Department of Clinical Medicine, Aalborg University, Copenhagen, DenmarkView further author information
,
Maria Antonietta Barbieri1 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark;3 Department of Clinical and Experimental Medicine, University of Messina, Messina, ItalyORCID Iconhttps://orcid.org/0000-0002-2019-4696View further author information
ORCID Icon,
Vera Battini1 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, Denmark;4 Pharmacovigilance & Clinical Research, International Centre for Pesticides and Health Risk Prevention, Department of Biomedical and Clinical Sciences (DIBIC), ASST Fatebenefratelli-Sacco University Hospital, Università Degli Studi Di Milano, Milan, ItalyORCID Iconhttps://orcid.org/0000-0002-3513-9593View further author information
ORCID Icon,
Eva Simoncic1 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DenmarkView further author information
,
Julien Kirchgesner5 Department of Gastroenterology, INSERM, Institut Pierre Louis d’Epidémiologie Et de Santé Publique, AP-HP, Hôpital Saint-Antoine, Sorbonne Université, Paris, FranceORCID Iconhttps://orcid.org/0000-0002-2314-9284View further author information
ORCID Icon,
Trond Ulven1 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DenmarkORCID Iconhttps://orcid.org/0000-0002-8135-1755View further author information
ORCID Icon &
Maurizio Sessa1 Department of Drug Design and Pharmacology, University of Copenhagen, Copenhagen, DenmarkORCID Iconhttps://orcid.org/0000-0003-0874-4744View further author information
ORCID Icon show all
Pages 17-29 | Received 08 Dec 2023, Accepted 08 Feb 2024, Published online: 20 Feb 2024

Figures & data

Figure 1 Hazard ratio of drugs associated with an increased risk of the study outcome.

Figure 1 Hazard ratio of drugs associated with an increased risk of the study outcome.

Figure 2 Risk difference of drugs associated with an increased risk of the study outcome.

Figure 2 Risk difference of drugs associated with an increased risk of the study outcome.

Figure 3 Lasso regression for variable selection prolonging time interval from CD to the study outcome. Log(λ) = 4.5 was chosen to get the optimal number of features.

Figure 3 Lasso regression for variable selection prolonging time interval from CD to the study outcome. Log(λ) = 4.5 was chosen to get the optimal number of features.

Figure 4 Hazard ratio of drugs associated with a prolonged time interval from the initial diagnosis of CD to the study outcome.

Figure 4 Hazard ratio of drugs associated with a prolonged time interval from the initial diagnosis of CD to the study outcome.

Figure 5 Risk difference of drugs associated with an increased time interval from CD diagnosis date to the study outcome date.

Figure 5 Risk difference of drugs associated with an increased time interval from CD diagnosis date to the study outcome date.

Data Sharing Statement

Data are stored on secure servers on Statistics Denmark and cannot be shared according to Statistics Denmark regulations. Access to Statistics Denmark servers and the associated data can be granted by Statistics Denmark upon adequate permissions.

Related research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.