Rapid synthesis of curcuminoid pyrazoles with antiviral effects through one-pot combinatorial modification of total curcuminoids

Figures & data

Figure 1 Structural formulae of compounds 1–4.

Figure 2 X-ray structure of compound 4 showing the atom labeling scheme.

Note: The C, N, O and Cl atoms are drawn as 30% thermal ellipsoids.

Table 1 The antiviral effects of compounds 1−4

Compound	MNCC (μΜ)	CC50 (μΜ)	IC50 (μΜ)	TI
1	12.5	50.0	12.5	4
2	25.0	50.0	12.5	4
3	<12.5	<12.5	>50.0	<1
4	<12.5	<12.5	>50.0	<1
Curcumin	>12.5	20.0	>50.0	<1

Note: TI = CC₅₀/IC₅₀.

Abbreviations: CC₅₀, the concentration that showed 50% cytotoxic effect; IC₅₀, 50% inhibition concentration; MNCC, maximal noncytotoxic concentration; TI, therapeutic index.