The Effects of High Fat Diet on the Incidence of Obesity and Monocyte Chemoattractant Protein-1 Levels on Histological Changes in Prostate Wistar Rats

Figures & data

Table 1 The Relationship of Fat Intake with Obesity

Diet	8-Week			16-Week
	Obese	No Obese	p-value	Obese	No Obese	p-value*
ND	0	6	0.005	0	6	0.005
HFD	4	2		4	2

Note: *Fisher’s exact test.

Abbreviations: ND, Normal diet; HFD, High fat diet.

Table 2 Differences in MCP-1 Levels and Cystic Dilatation of the Prostate Gland Between HFD and ND Groups

Variable	Diet	8-Week		16-Week
		n/Mean (SD)	P-value	n/Mean (SD)	P-value*
MCP-1 (μg/mL)	ND	6/15.66 (1.32)	p<0.001	6/17.54 (1.07)	p<0.001
	HFD	6/18.87 (0.76)		6/21.27 (1.06)
Prostate gland with cystic dilatation (percentage)	ND	6/47.24 (13.84)	p=0.053	6/56.39 (9.28)	p=0.037
	HFD	6/63.46 (11.72)		6/67.79 (6.00)

Note: *Fisher’s exact test.

Abbreviations: HFD, High fat diet; ND, Normal diet of fat; SD, standard deviation; MCP-1, monocyte chemoattractant protein-1.

Table 3 Correlation Between Levels of MCP-1, Percentage of Prostate Glands Subjected to Cystic Dilatation

Variable	Prostate Gland Undergoing Cystic Dilatation (%)
	8-Week	16-Week
MCP-1 (μg/mL)	r=0.406 (p=0.095)	r=0.713 (p<0001)

Abbreviation: MCP-1, monocyte chemoattractant protein-1.

Table 4 MCP-1 Levels Circulation and Prostate Gland Percentage Experiencing Cystic Dilatation in Mice That Got HFD

Variable	Obesity	8-Week HFD (n=6)		16-Week HFD (n=6)
		n/Mean (SD)	P-value	n/Mean (SD)	P-value
MCP-1 (μg/mL)	Yes	4/18.68 (0.80)	p=0.448	4/20.90 (1.14)	p=0.278
	Not	2/19.25 (0.76)		2/21.99 (1.06)
Prostate gland with cystic dilatation (percentage)	Yes	4/63.03 (14.43)	p=0.914	4/63.03 (1.06)	p=0.893
	Not	2/64.34 (7.72)		2/64.34 (7.73)

Abbreviations: HFD, High fat diet; ND, Normal diet of fat; SD, standard deviation; MCP-1, monocyte chemoattractant protein-1.