Lujo virus: current concepts

Figures & data

Table 1 Clinical signs and symptoms of five patients with Lujo hemorrhagic fever

Sign or symptom	No. of patients manifesting the symptom	Mean day of illness in which sign or symptom first appeared (range)	Comments
Fever	5/5	1 (–)	Range: 38.2°C–40°C
Myalgia	5/5	1.2 (1–2)
Sore throat or pharyngitis	5/5	3.2 (1–6)
Nausea and/or vomiting	4/5	4.3 (2–8)
Diarrhea	4/5	4.5 (2–7)	All diarrhea was nonbloody
Rash	4/5	5.8 (4–8)	Typically maculopapular, starting on the torso and spreading to the limbs
Oliguria	3/5	9.3 (7–11)
Hemorrhage (excluding subconjunctival hemorrhage)	5/5	5.5 (3–8)	Includes vaginal bleeding (1/5, day 3), pharyngeal ecchymoses (2/5, days 6 and 7) and bleeding at central vein catheter insertion site (2/5, days 7 and 8), injection sites
Subconjunctival injection or hemorrhage	3/5	6.7 (6–7)
Facial and/or neck swelling	4/5	7.0 (5–9)
Neurologic signs	2/5	7.5 (5–10)	Includes tremor (1/5, day 5) and seizures (1/5, day 10)

Notes: Signs and symptoms are listed in order of appearance during the course of infection. Only the manifestations noted during the first 2 weeks of illness are shown. Adapted from Sewlall NH, Richards G, Duse A, et al. Clinical features and patient management of lujo hemorrhagic fever. PLoS Negl Trop Dis. 2014;8(11):e3233.³