Variability, asymmetry and bilateral coordination of gait during single- and dual-task walking of patients with cerebral small vessel disease

Abstract

Objective

We investigated coefficient of variation (CV), gait asymmetry (GA) and phase coordination index (PCI) in cerebral small vessel disease (CSVD) patients during single-task walking (STW) and dual-task walking (DTW) and explored the relationship between above parameters with disease severity and cognitive function.

Methods

This cross-sectional study collected cognitive function indices and gait parameters from 23 healthy controls and 94 patients with CSVD during STW and DTW. According to the Fazekas scales, the severity of CSVD valued by white matter hyperintensity (WMH) were divided into control, mild, moderate, severe and control group. MRIs were analyzed for WMHs, CMB, lacunes, etc.

Results

The control group showed lower PCI than CSVD patients during STW; no differences were detected among the disease severity groups. During DTW, all four groups exhibited significant differences in PCI and CV. For the moderate and severe groups, coordination and variation significantly differed between the two walking methods. There were correlations between the PCI and GA in the moderate and severe groups (R = 0.376, R = 0.573 during DTW; R = 0.414, R = 0.643 during STW) and no correlations in the control group and mild CSVD group.

Conclusion

PCI and CV may be vital for detecting the symptoms in the early stage of CSVD disease. We also verified that the PCI could become the bridge across the cognition and motor disorder in CSVD, which was helpful for evaluating clinical symptoms comprehensively.

Keywords:

• Cerebral small vessel disease
• dual-task walking
• phase coordination index
• gait asymmetry
• coefficient of variation

Disclosure statement

No potential conflict of interest was reported by the author(s)

Additional information

Funding

This study was supported by the Wu Jieping Foundation [grant number 320.6750.18456]. The funding agency had no role in study design; in the collection, analysis and interpretation of data; in the writing of the report and in the decision to submit the article for publication.