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Sulfur Letters Volume 26, 2003 - Issue 4
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Original Articles

Novel disulfides as anticancer/antimalarial agents

Grace Kong The Toronto General Hospital and the University of Toronto, Tropical Disease Unit, Toronto, Ontario, Canada, M5S 1A8
,
Kevin C. Kain The Toronto General Hospital and the University of Toronto, Tropical Disease Unit, Toronto, Ontario, Canada, M5S 1A8
,
Ian Crandall The Toronto General Hospital and the University of Toronto, Tropical Disease Unit, Toronto, Ontario, Canada, M5S 1A8
&
Richard F. Langler Mount Allison University, Department of Chemistry, Sackville, New Brunswick, Canada, E4L 1G8Correspondence[email protected]
Pages 149-154 | Published online: 08 Jun 2010
 

Abstract

The antimalarial/anticancer (human skin cancer) properties of 11 small organosulfur compounds, some of which show antifungal and antileukemic activity, were determined using in vitro assays. Some compounds had little or no antimalarial/anticancer activity while others were highly active with IC50 values in the low µM range. Three disulfides (3, 7, 9) show encouraging activity, viz: low activity against CHO (representative mammalian) cells and significantly higher activity against human malaria (Plasmodium falciparum) cells and human skin cancer (C32) cells.

RFL thanks the Medical Research Fund of New Brunswick for financial support. KCK is supported by a career award from the Ontario Ministry of Health.

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