https://orcid.org/0000-0001-9813-4039
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ABSTRACT
The correct selection of ethanol-intoxicated patients that require ICU admission is crucial for reducing morbidity and mortality. This study included 165 patients intoxicated with ethanol, confirmed by blood analysis. The patients were divided into ICU group = 46 and inward group = 119. We created a new predictive score based on seven parameters of APACHE II score and seven laboratory parameters that were significant in ICU-admitted patients by giving each parameter one point. The new predictive score achieved a sensitivity of 87, a specificity of 93.3, and an area under the curve of 0.967 with a cutoff >6. On the other hand, blood ethanol level (BEL) exhibited a weak correlation with both APACHE II and new predictive scores and a weak correlation with the parameters of the new predictive score. The new predictive score included 14 parameters. This score can be used in predicting whether patients need ICU admission during assessment for ethanol intoxication in emergency rooms, independent of BEL analysis. It could potentially reduce morbidity and mortality.
KEYWORDS:
Disclosure statement
No potential conflict of interest was reported by the author(s).
Authors’ contributions
All authors contributed equally to the collection of data, data analysis, and writing of the present study. In addition, the article was revised by the corresponding author.
Ethics Statement
The study was conducted after the approval of the Aseer Institutional Review Board (No. H-06-B-091) in a date of 2022-Dec-27. The procedures followed in accordance with the ethical standards of the responsible committee on regional human experimentation and with the Helsinki Declaration of 1975.
Data availability statement
The datasets created and analyzed for the current study are not publicly accessible for patient privacy; however, they are available from the corresponding author upon justifiable request.
Abbreviations
| APACHE II | = | acute physiology and chronic health evaluation II |
| GC/FID | = | gas chromatography/flame ionization detector |
| ICU | = | intensive care unit |
| PaO2 | = | partial arterial pressure of oxygen |
| PaCo2 | = | partial arterial pressure of carbon dioxide |
| GCS | = | Glasgow coma scale |
| BGL | = | blood glucose level |
| LDH | = | lactate dehydrogenase |
| BUN | = | blood urea nitrogen |
| BEL | = | blood ethanol level |
| ARDS | = | acute respiratory distress syndrome |
| SAP | = | Severe acute pancreatitis |
| SIRS | = | systemic inflammatory response syndrome |
| ACM | = | Alcohol cardiomyopathy |
| OTARR | = | Online Toxicology Analysis Requests and Results |
| RRS | = | rapid response system |
| Na | = | sodium |
| GCS | = | Glasgow coma scale |
| FiO2 | = | fraction of inspired oxygen |
| Pao2 | = | partial pressure of oxygen |
| PaCo2 | = | partial pressure of carbone dioxide |
| K | = | potassium |
| Cr | = | creatinine |
| HCO3 | = | bicarbonates |
| AST | = | aspartate aminotransferase |
| HCT | = | hematocrit |
| ECHO | = | echocardiography |
| LVEF | = | Left ventricular ejection fraction |
| LVD | = | left ventricular end-diastolic dimension |
| ROC | = | the receiver operating characteristic |
| IQR | = | interquartile range |
| AUC | = | area under curve |