Serum hepcidin and paraoxonase levels in patients with severe, moderate, and mild obstructive sleep apnea hypopnea syndrome (OSAS): A comparison between OSAS patients and simple snoring patients

ABSTRACT

Objective

To investigate the importance of hepcidin and paraoxonase in obstructive sleep apnea syndrome (OSAS).

Methods

Eighty-eight patients with sleep disorders were included and divided into four groups: simple snoring (SS), mild, moderate, and severe OSAS. All patients underwent polysomnography. The hepcidin and paraoxonase levels were examined and compared between the groups.

Results

There were significant differences between the four groups in terms of paraoxonase levels. In the SS group, the paraoxonase value was significantly higher than in the other three groups. In the analysis, Apnea Hypopnea Index (AHI) was negatively correlated with paraoxonase levels.

Conclusion

A significant difference was found between the OSAS groups with respect to paraoxonase enzyme, and a negative correlation with AHI was observed. Paraoxonase level could be used as a biomarker in OSAS. No significant data was found for hepcidin levels; therefore, hepcidin cannot be used as a biomarker in OSAS.

KEYWORDS:

• OSAS
• paraoxonase
• hepcidin

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

There is a source of support in the form of an Antalya Education and Research Hospital thesis grant.