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Original Article

Impact of HLA-B51 on Uveitis and Retinal Vasculitis: Data from the AIDA International Network Registries on Ocular Inflammatory Disorders

Jurgen Sotaa Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
, MD,
Silvana Guerrierob DiBrain Department, University of Bari, Bari, ItalyView further author information
, MD,
Giuseppe Lopalcoc Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, ItalyView further author information
, MD,
Abdurrahman Tufand Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, TurkeyView further author information
, MD,
Gaafar Ragabe Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, Egypt;f Faculty of Medicine, Newgiza University, Giza, EgyptView further author information
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Ibrahim AlMaglouthg Rheumatology Unit, Department of Medicine, King Saud University, Riyadh, Saudi ArabiaView further author information
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Marcello Govonih Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, ItalyView further author information
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Petros P. Sfikakisi Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Athens, GreeceView further author information
, MD,
Micol Frassij Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyView further author information
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Antonio Vitalea Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
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Riza Can Kardasd Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, TurkeyView further author information
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Paola Triggianesek Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyView further author information
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Maria Sole Chimentik Rheumatology, Allergology and Clinical Immunology, Department of Systems Medicine, University of Rome Tor Vergata, Rome, ItalyView further author information
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Aos A. Aboabatg Rheumatology Unit, Department of Medicine, King Saud University, Riyadh, Saudi ArabiaORCID Iconhttps://orcid.org/0000-0003-2468-4171View further author information
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Matteo Pigal Rheumatology Unit, Department of Medical Sciences, University and AOU of Cagliari, Cagliari, ItalyView further author information
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Sara Montim Rheumatology Department institution, IRCCS Policlinico S. Matteo Fondazione, University of Pavia, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Pavia, ItalyView further author information
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Gian Domenico Sebastianin U.O.C. Reumatologia, Ospedale San Camillo-Forlanini, Rome, ItalyView further author information
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Derya Yildirimd Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, TurkeyView further author information
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Alessandro Confortio U.O. Medicina Generale, Ospedale San Paolo di Civitavecchia, Rome, ItalyView further author information
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Stefano Gentileschia Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
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Rosanna Dammaccob DiBrain Department, University of Bari, Bari, ItalyView further author information
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Andrea Hinojosa-Azaolap Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoView further author information
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Perla Ayumi Kawakami-Camposq Department of Ophthalmology, Department of Immunology and Rheumatology Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoView further author information
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Francesca Ruffillih Rheumatology Unit, Department of Medical Sciences, Azienda Ospedaliero-Universitaria S. Anna-Ferrara, University of Ferrara, Ferrara, ItalyView further author information
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Jiram Torres-Ruizp Department of Immunology and Rheumatology, Instituto Nacional de Ciencias Médicas y Nutrición Salvador Zubirán, Mexico City, MexicoView further author information
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Maissa Thabetr Internal Medicine Department, Farhat Hached University Hospital, Faculty of Medicine of Sousse, University of Sousse, Sousse, TunisiaView further author information
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Amira Atigr Internal Medicine Department, Farhat Hached University Hospital, Faculty of Medicine of Sousse, University of Sousse, Sousse, TunisiaView further author information
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Piero Ruscittis Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, ItalyView further author information
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Giulia Cataldis Rheumatology Unit, Department of Biotechnological and Applied Clinical Sciences, University of L’Aquila, L’Aquila, ItalyView further author information
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Ombretta Viapianat Rheumatology Unit, Department of Medicine, University and Azienda Ospedaliera Universitaria Integrata of Verona, Verona, ItalyView further author information
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Gülen Hatemiu Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey;v Behçet’s Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, TurkeyView further author information
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Alican Karakoçu Department of Internal Medicine, Division of Rheumatology, Cerrahpasa Medical School, Istanbul University-Cerrahpasa, Istanbul, Turkey;v Behçet’s Disease Research Center, Istanbul University-Cerrahpasa, Istanbul, TurkeyView further author information
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Stefania Costiw Unit of Pediatric Rheumatology, ASST Gaetano Pini-CTO, Milan, ItalyView further author information
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Annamaria Iagnoccox Academic Rheumatology Center, Dipartimento Scienze Cliniche e Biologiche, Università degli Studi di Torino, Turin, ItalyView further author information
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Francesca Crisafullij Rheumatology and Clinical Immunology, Spedali Civili and Department of Clinical and Experimental Sciences, University of Brescia, Brescia, ItalyView further author information
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George Fragoulisi Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Athens, GreeceView further author information
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Emanuela Del Giudicey Pediatric and Neonatology Unit, Department of Maternal Infantile and Urological Sciences, Sapienza University of Rome, Polo Pontino, Latina, ItalyORCID Iconhttps://orcid.org/0000-0002-3334-4884View further author information
, MDORCID Icon,
Mohamed Tharwat Hegazye Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, Egypt;f Faculty of Medicine, Newgiza University, Giza, EgyptView further author information
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Maria Pia Paroliz Uveitis Unit, Department of Sense Organs, Eye Clinic, Sapienza University of Rome, Rome, ItalyView further author information
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Ali Şahinaa Division of Rheumatology, Department of Internal Medicine, Sivas Cumhuriyet University Medical Faculty, Sivas, TurkeyView further author information
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Maria Morronec Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, ItalyView further author information
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Florenzo Iannonec Department of Precision and Regenerative Medicine and Ionian Area (DiMePRe-J), Policlinic Hospital, University of Bari, Bari, ItalyView further author information
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Daniela Opris-Belinskibb Rheumatology and Internal Medicine Department, Carol Davila University of Medicine and Pharmacy, Bucharest, RomaniaView further author information
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Kazi Nur Asfinacc College of Medicine Research Center, King Saud University, Riyadh, Saudi ArabiaView further author information
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Patrizia Baronedd Department of Clinical and Experimental Medicine, University of Catania, Catania, ItalyView further author information
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Carla Gaggianoa Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
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Hamit Kucukd Division of Rheumatology, Department of Internal Medicine, Gazi University Hospital, Ankara, TurkeyView further author information
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Maria Francesca Gicchinoee Department of Woman, Child and of General and Specialized Surgery, University of Campania “Luigi Vanvitelli”, Naples, ItalyView further author information
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Francesco Carubbiff Department of Life, Health & Environmental Sciences and Internal Medicine and Nephrology Unit, Department of Medicine, University of L’Aquila and ASL Avezzano-Sulmona-L’Aquila, San Salvatore Hospital, L’Aquila, ItalyView further author information
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Valeria Caggianoa Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
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Katerina Laskarii Joint Academic Rheumatology Program, National and Kapodistrian University of Athens Medical School, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory and Autoimmune Diseases (RITA) Center], Athens, GreeceView further author information
, MD,
Samar Tharwatgg Rheumatology and Immunology Unit, Internal Medicine Department, Mansoura University, Mansoura, Egypt;hh Department of Internal Medicine, Faculty of Medicine, Horus University, New Damietta, EgyptView further author information
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Haner Direskeneliii Department of Internal Medicine, Division of Rheumatology, School of Medicine, Marmara University, Istanbul, TurkeyView further author information
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Fatma Alibaz-Onerii Department of Internal Medicine, Division of Rheumatology, School of Medicine, Marmara University, Istanbul, TurkeyView further author information
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Gizem Sevikii Department of Internal Medicine, Division of Rheumatology, School of Medicine, Marmara University, Istanbul, TurkeyView further author information
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Armin Maierjj Rheumatology Unit, Department of Medicine, Central Hospital of Bolzano, Bolzano, ItalyView further author information
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Ahmed Hatem Laymounae Internal Medicine Department, Rheumatology and Clinical Immunology Unit, Faculty of Medicine, Cairo University, Giza, EgyptView further author information
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Giacomo Emmikk Department of Experimental and Clinical Medicine, University of Florence, Florence, Italy;ll Centre for Inflammatory Diseases, Department of Medicine, Monash Medical Centre, Monash University, Melbourne, AustraliaView further author information
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Nurullah Akkoçmm Division of Rheumatology, Department of Internal Medicine, School of Medicine, Manisa Celal Bayar University, Manisa, TurkeyView further author information
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Maria Tarsiaa Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
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Jessica Sbalchieroa Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
, MD,
Giovanni Continn Pediatric Nephrology and Rheumatology Unit, Azienda Ospedaliero Universitaria (AOU) G Martino, Messina, ItalyView further author information
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Rosaria Spinellaoo Ophthalmology Clinic, Department of Biomedical Sciences, University of Messina, Messina, ItalyView further author information
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Francesco La Torrepp Department of Pediatrics, Giovanni XXIII Pediatric Hospital, University of Bari, Bari, ItalyView further author information
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Enrico Tombettiqq Department of Biomedical and Clinical Sciences, Fatebenefratelli Hospital, Università di Milano, Milan, ItalyView further author information
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Rana Hussein Aminrr Ophthalmology Department, Faculty of Medicine, Cairo University, Cairo, EgyptView further author information
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Angela Mauross Pediatric Rheumatology Unit, Department of Childhood and Developmental Medicine, Fatebenefratelli-Sacco Hospital, Milan, ItalyView further author information
, MD,
Anastasios Karamanakostt Department of Rheumatology, Evangelismos General Hospital, Athens, GreeceView further author information
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Ester Carreñouu Department of Ophthalmology, Fundación Jiménez Díaz University Hospital (FJD), Madrid, SpainView further author information
, MD,
Alex Fonollosavv Department of Ophthalmology, Biocruces Bizkaia Health Research Institute, Cruces University Hospital, Barakaldo, SpainView further author information
, MD,
Marco Cattaliniww Pediatric Clinic, University of Brescia and Spedali Civili di Brescia [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Brescia, ItalyView further author information
, MD,
Luciana Bredaxx Pediatric Rheumatology Unit, S.S. Annunziata Hospital, Chieti, ItalyView further author information
, MD,
Alejandra de-la-Torreyy Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaORCID Iconhttps://orcid.org/0000-0003-0684-1989View further author information
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Ewa Wiesik-Szewczykzz Department of Internal Medicine, Pneumonology, Allergology and Clinical Immunology, Central Clinical Hospital of the Ministry of National Defense, Military Institute of Medicine, National Research Institute, Warsaw, PolandView further author information
, MD,
Carlos Cifuentes-Gonzálezyy Neuroscience Research Group (NEUROS), Neurovitae Center for Neuroscience, Institute of Translational Medicine (IMT), School of Medicine and Health Sciences, Universidad del Rosario, Bogotá, ColombiaORCID Iconhttps://orcid.org/0000-0002-2703-0977View further author information
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Seza Ozenaaa Pediatric Rheumatology Unit, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, TurkeyView further author information
, MD,
Maria Antonietta Mazzeiaaa Pediatric Rheumatology Unit, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, TurkeyView further author information
, MD,
Gian Marco Tosiccc Ophthalmology Unit, Department of Medicine, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
, MD,
Bruno Frediania Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
, MD,
Alberto Balistreriddd Bioengineering and Biomedical Data Science Lab, Department of Medical Biotechnologies, University of Siena, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyView further author information
, MD,
Ezgi Deniz Batuaaa Pediatric Rheumatology Unit, Department of Pediatrics, Hacettepe University School of Medicine, Ankara, TurkeyView further author information
, MD,
Vishali Guptaeee Advanced Eye Centre, Postgraduate Institute of Medical Education and Research, Chandigarh, IndiaView further author information
, MD,
Luca Cantarinia Rheumatology Unit, Department of Medical Sciences, Surgery and Neurosciences Department of Medical Sciences, Surgery and Neurosciences, University of Siena and Azienda Ospedaliero-Universitaria Senese [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyCorrespondence[email protected]
View further author information
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Claudia Fabianibbb Unit of Diagnostic Imaging, Department of Medical, Surgical and NeuroSciences and of Radiological Sciences, University of Siena, Azienda Ospedaliero-Universitaria Senese, [European Reference Network (ERN) for Rare Immunodeficiency, Autoinflammatory, and Autoimmune Diseases (RITA) Center], Siena, ItalyCorrespondence[email protected]
ORCID Iconhttps://orcid.org/0000-0003-4515-7741View further author information
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Received 20 Nov 2023, Accepted 19 Apr 2024, Published online: 17 May 2024
 
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ABSTRACT

Purpose

The clinical relevance of human leukocyte antigen (HLA) subtypes such as HLA-B51 on Behçet’s disease (BD)-related uveitis and non-infectious uveitis (NIU) unrelated to BD remains largely unknown.

Methods

Data were prospectively collected from the International AIDA Network Registry for BD and for NIU. We assessed differences between groups (NIU unrelated to BD and positive for HLA-B51, BD-related uveitis positive for HLA-B51 and BD-related uveitis negative for HLA-B51) in terms of long-term ocular complications, visual acuity (VA) measured by best corrected visual acuity (BCVA), anatomical pattern, occurrence of retinal vasculitis (RV) and macular edema over time.

Results

Records of 213 patients (341 eyes) were analyzed. No differences in complications were observed (p = 0.465). With regard to VA, a significant difference was detected in median BCVA (p = 0.046), which was not maintained after Bonferroni correction (p = 0.060). RV was significantly more prevalent in NIU-affected patients who tested positive for HLA-B51, irrespective of the systemic diagnosis of BD (p = 0.025). No differences emerged in the occurrence of macular edema (p = 0.99).

Conclusions

Patients with NIU testing positive for HLA-B51 exhibit an increased likelihood of RV throughout disease course, irrespective of a systemic diagnosis of BD. The rate of complications as well as VA are comparable between NIU cases unrelated to BD testing positive for HLA-B51 and uveitis associated with BD. Therefore, it is advisable to perform the HLA-B typing in patients with NIU or retinal vasculitis, even in the absence of typical BD features.

Author contribution statement

JS, LC and CF have designed the study and wrote the first draft. All authors have been involved in patients enrollment and revision of the manuscript. All authors have given final approval of the manuscript.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Correction Statement

This article has been corrected with minor changes. These changes do not impact the academic content of the article.

Additional information

Funding

The author(s) reported there is no funding associated with the work featured in this article.

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