Cell toxicity assessment in co-treatment to metalworking fluids and vibration: an in vitro study of occupational exposure setting

ABSTRACT

This study was designed to study dual risk of MWFs and vibration according to exposure simulation of selected industry. Air samples of two types MWFs were evaluated according to NIOSH 5026. Vibration acceleration exposure was assessed based on the ISO 8041:2005 standard. Cell treatment of both MWF air samples and vibration as the same as dual exposure to MWF airborne and vibration was assessed. There is a potency of nitrosamine formation in airborne samples of ethylamine containing MWF, while heterocyclic including bore is found in airborne bore containing MWF. DNA breaks caused by boron-containing MWF were higher than nitrosamine air samples. Oxidative stress production and chronic inflammation were highlighted in the response to cell treatments. The risk of cell toxicity in machining workers was evaluated at a level lower than the occupational exposure limit for MWFs and vibration.

KEYWORDS:

• Metalworking fluids
• vibration
• occupational exposure
• DNA impairment
• chronic inflammation

Acknowledgements

The authors of this article are grateful to the Department of Biophysics of Tarbiat Modares University, and Air Quality and Climate Change Research Center with the proposal number 43007208, Shahid Beheshti University of Medical Sciences, Thehran, Iran.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors contributions

Zahra Moradpour: investigation, project administration, writing original draft, and writing – review and editing. Ali Khavanin: Methodology and writing – Original Draft. Parviz Abdolmaleki: resources, conceptualization, writing the original draft. Behnam Hajipour-verdom: project administration, writing and editing. Seyed Javad Mola: Software, writing and review. Mansoureh Hamidi: Methodology and writing – Original Draft. Rezvan Zendehdel: Supervision, methodology, writing original draft, and writing – review and editing.

Data availability statement

The datasets generated during analysis during the current study are available.

Consent to participate and publish

All authors read the manuscript and agree with submission and publish to International Journal of Environmental Health Research.

Additional information

Funding

This work was supported by the Shahid Beheshti University of Medical Sciences.