Bisphenol derivatives in cord blood and association between thyroid hormones and potential exposure sources

ABSTRACT

Endocrine-disrupting environmental chemicals are a public health concern, particularly fetal exposure to Bisphenol derivatives. This study aimed to assess fetal exposure to Bisphenol derivatives (BPA, BPF, and BPS) by measuring their levels in cord blood and investigating their association with plastic material used in daily life as well as cord blood TSH and free L-thyroxine (fT₄) levels. In this descriptive study, a questionnaire with a face-to-face interview was administered before birth, and cord blood samples were taken immediately after delivery. The mean levels of BPA, BPF, TSH, and fT₄ were measured as 10.69 ± 2.39 ng/ml, 3.80 ± 0.58 ng/ml; 2.36 ± 0.23 µIU/ml, and 14.18 ± 0.53 pg/ml, respectively, in a total of 104 cord blood samples. All BPS levels remained below the detection limit. Linear regression analysis revealed a positive association between birth weight and cord blood BPA concentration (β = 0.26; p = 0.02). Further research on maternal exposure during the fetal and neonatal period is critical for public health.

KEYWORDS:

• Thyroid hormone
• endocrine disruptors
• bisphenols

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethical approval

Ethical approval was obtained from Hacettepe University Non-Interventional Clinical Research Ethics Committee (26.05.2021/16969557–1099).

Consent to participate & publish

Participation and publication approval were obtained from all authors.

Availability of data and materials

Data sharing is not applicable to this article as no datasets were generated or analysed during the current study.

Additional information

Funding

The work was supported by the Hacettepe Üniversitesi [THD-2021-19595].