Peiminine alleviate coliti-like phenotype in mice induced by lead exposure

ABSTRACT

The deleterious impact of lead (Pb) pollution on human health is evident in both domestic and occupational settings, provoking an inflammatory response across multiple tissue, limited attention has been devoted to its adverse effects on colitis and the underlying mechanisms. Peiminine (PMI) has been recognized for its anti-inflammatory properties, yet its specific anti-inflammatory effects in lead-induced colitis models remain elusive. Through the establishment of both in vivo and in vitro lead exposure models, suggests that lead exposure can induce colitis and that PMI regulates lead exposure-induced colitis by inhibiting the NF-kB signaling pathway, and alleviates the ability of lead to apoptosis and inflammation levels in intestinal epithelial cells. Consequently, these results present a promising avenue for further exploration of the molecular mechanisms underlying lead-induced colitis, evaluation of the associated risks linked to lead exposure, and the development of therapeutic interventions for colitis resulting from lead exposure.

KEYWORDS:

• Lead exposure
• Peiminine
• colitis
• inflammation
• NF-kB signaling pathway

Disclosure statement

No potential conflict of interest was reported by the author(s).

Authors’ contributions

Jing Zhang conceptualised the experiments, Chenchen Wang, Yixuan He and Ying Wang managed the animal experimentation, Xinbei Fang, Meimei Shi, Hui Chen, Jianbin Zhang and Haijiang Zou managed the laboratory assays, Jing Zhang wrote the first draft of the manuscript. All authors read and approved the final draft and submission of the manuscript.

Additional information

Funding

This work was supported by grants from the National Natural Science Foundation of China (82001156 and 82000573).