Symmetrical structure design of PLGA Biodegradable sinus stents and structure optimization based on surrogate models

Abstract

This study aims to enhance the degradation uniformity of PLGA sinus stents to minimize fracture risk caused by stress corrosion. Symmetric stent structures were introduced and compared to sinusoidal structure in terms of stress and degradation uniformity during implantation and degradation processes. Three surrogate models were employed to optimize the honeycomb-like structure. Results showed honeycomb-like structures exhibited the superior stress distribution and highest degradation uniformity. The kriging model achieved the smallest error and degradation uniformity of 83.24%. In conclusion, enhancing the symmetry of stent structures improves degradation uniformity, and the kriging model has potential for the optimization of stent structures.

Keywords:

• PLGA biodegradable sinus stent
• symmetrical structure design
• stress corrosion model
• surrogate model

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the National Natural Science Foundation of China [12172034, U20A20390, 11827803], the 111 project [B13003], and the Fundamental Research Funds for Central Universities.