Lactobacillus group and arterial hypertension: A broad review on effects and proposed mechanisms

Abstract

Hypertension is the leading risk factor for cardiovascular diseases and is associated with intestinal dysbiosis with a decrease in beneficial microbiota. Probiotics can positively modulate the impaired microbiota and impart benefits to the cardiovascular system. Among them, the emended Lactobacillus has stood out as a microorganism capable of reducing blood pressure, being the target of several studies focused on managing hypertension. This review aimed to present the potential of Lactobacillus as an antihypertensive non-pharmacological strategy. We will address preclinical and clinical studies that support this proposal and the mechanisms of action by which these microorganisms reduce blood pressure or prevent its elevation.

Keywords:

• ACE inhibition
• antihypertensive
• blood pressure
• probiotic

Disclosure statement

The authors report no conflict of interest.

Additional information

Funding

This work was supported by the Conselho Nacional de Desenvolvimento Científico e Tecnológico (CNPq), Coordenação de Aperfeiçoamento de Pessoal de Nível Superior – Brazil (CAPES) – Finance Code 001, and Paraiba State Research Foundation (FAPESQ) under Grant ID:007/2019 FAPESQ-PB-MCT/CNPq.