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Journal of Herbs, Spices & Medicinal Plants Volume 30, 2024 - Issue 1
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Research Article

In Vitro Biological Activity Screening of Arbutus Unedo Leaves in Light of Their Traditional Use

Ricardo Nunesa Food Science Laboratory, MED – Mediterranean Institute for Agriculture, Environment and Development & CHANGE – Global Change and Sustainability Institute, Faculty of Science and Technology, University of Algarve, Faro, PortugalView further author information
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Isabel S. Carvalhoa Food Science Laboratory, MED – Mediterranean Institute for Agriculture, Environment and Development & CHANGE – Global Change and Sustainability Institute, Faculty of Science and Technology, University of Algarve, Faro, PortugalCorrespondence[email protected]
View further author information
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Paweł Paśkob Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information
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Małgorzata Tyszka – Czocharab Department of Food Chemistry and Nutrition, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information
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Agnieszka Szewczykc Department of Pharmaceutical Botany, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information
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Marek Szlósarczykd Department of Inorganic and Analytical Chemistry, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information
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Irma Podolake Department of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information
&
Agnieszka Galantye Department of Pharmacognosy, Faculty of Pharmacy, Medical College, Jagiellonian University, Krakow, PolandView further author information
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Pages 68-82 | Received 14 Jun 2023, Published online: 05 Sep 2023
 
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ABSTRACT

The biological activity of A. unedo leaves, in relation to their traditional medicinal use in treating gastrointestinal and urinary tract diseases was verified. The ethanol extract of the leaves was quantitatively described in terms of flavonoids and phenolic acids (RP-HPLC), and zinc (voltametric analysis) and subjected to cytotoxic (MTT), antioxidant (TPC, TFC, TAA, RP, DPPH, and FRAP), antibacterial (disc diffusion), and antidiabetic assays (enzyme inhibition) in vitro. The extract was highly cytotoxic against prostate cancer cells, with less impact on colon carcinomas, while being nontoxic to normal prostate and kidney cells, and demonstrated antioxidant and antidiabetic activities.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This work was supported by the Fundação para a Ciência e a Tecnologia of Portugal [SFRH/BDE/51888/2012].

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