Origanum Compactum Essential Oil Ameliorates Triton WR-1339-Induced Hyperlipidemia in Rats: Chemical Composition and Acute Toxicity

ABSTRACT

The impact of Origanum compactum essential oil (EO) at 80 mg kg⁻¹ on Triton WR-1339-induced hyperlipidemia in rats was investigated.The EO’s phytochemical composition revealed the predominance of carvacrol (35.71%), p-cymene (13.74%), and carvacrol methyl ether (11.71%). Triton WR-1339 led to elevations in total cholesterol (TC), triglycerides (TGs), low-density lipoprotein cholesterol (LDL-C), very low-density lipoprotein cholesterol (VLDL-C), as well asatherogenic indices encompassing the atherogenic coefficient (AC), Castelli’s risk index I (CRI-I), and Castelli’s risk index II (CRI-II). Conversely, pretreatment with O. Compactum EO for sevendays exerted a preventive effect against the increase of TC, TGs, LDL-C, VLDL-C, AC, CRI-I.

KEYWORDS:

• Antihyperlipidemic effect
• medicinal plants
• toxicity
• LD₅₀

Disclosure statement

No potential conflict of interest was reported by the author(s).

Ethics Approval

All experiments were performed according to the local ethical committee, Faculty of Science and Techniques Errachidia, Morocco, number FSTE/2015.

Abbreviations

AC	=	Atherogenic coefficient
CRI	=	Castelli’s risk index
EO	=	Essential oil
HDL-C	=	High-density lipoprotein cholesterol
HMG-CoA reductase	=	Hydroxymethyl-glutaryl coenzyme A reductase
LDL-C	=	Low-density lipoprotein cholesterol
TC	=	Total cholesterol
TGs	=	Triglycerides
VLDL-C	=	Very-low-density lipoprotein cholesterol

Additional information

Funding

This work was supported by the CNRST under grant N° PPR/2015/35.