Abstract
Background
The pineal product melatonin (MEL) modulates blood vessels through G protein-coupled receptors (GPCRs) called melatonin type 1 receptor (MT1R) and melatonin type 2 receptor (MT2R), in that order. The renin-angiotensin system (RAS), which breaks down angiotensin II (Ang II) to create Ang 1–7, is thought to be mostly controlled by angiotensin-converting enzyme-2 (ACE2).
Aim
The current work examines the involvement of ACE2 inhibitor, MEL, and ramelteon (RAM) in the vascular response to Ang II activities in the endothelial denuded (E-) and intact (E+) rat isolated thoracic aortic rings.
Method
The isometric tension was measured to evaluate the vascular Ang II contractility using dose response curve (DRC).
Results
MEL and RAM caused a rightward shift of Ang II in endothelium E + and endothelium E- aorta.
Conclusion
According to the current study, the distribution of MEL receptors and the endothelium’s condition are related to the vasomodulatory effect of MEL and ACE2 on Ang II attenuation. These physiological interactions can control vascular tone and increase Ang II reactivity denude endothelial layaer.
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Acknowledgement
The authors acknowledge the financial support of the work by Mohammed Saadi Ahmed the Chairman of Erbil Bank, Iraq for investment and finance.
Disclosure statement
No potential conflict of interest was reported by the author(s).
Ethical approval
This study complies with the Declaration of the ARRIVE guidelines and was performed according to ethics committee approval.