Daptomycin and ceftaroline combination for the treatment of persistent methicillin-resistant Staphylococcus aureus bloodstream infections: a case series and literature review

Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) is challenging to treat due to a lack of guidance for clinicians. The daptomycin and ceftaroline combination is promising for treating persistent MRSA bloodstream infections (BSIs). In this report, we present a case series of 7 patients who failed vancomycin and then were treated with daptomycin and ceftaroline for persistent MRSA BSIs. The median age (IQR) of the included patients was 59 (48–67), with 5 male and 2 female patients. Six patients (85.7%) had a clinical cure for their persistent BSIs. The median time (IQR) for sterilization of MRSA BSIs after initiation of daptomycin and ceftaroline combination was 2 days (1–3). Among the patients who had clinical cures, the median time for clinical cures (IQR) was 6 weeks (4.5–6 weeks). The combination of daptomycin and ceftaroline could be an excellent treatment option for persistent MRSA BSIs.

Keywords:

• Daptomycin
• ceftaroline
• MRSA
• bloodstream infections
• bacteremia
• antimicrobial resistance

Acknowledgment

We would like to thank Fadi Shehadeh, Infectious Diseases Division, Brown University, Rhode Island, United States, for identifying the patients from the electronic health record on daptomycin and ceftaroline.

Authors’ contributions

Y.S.A.: conceptualization, methodology, formal analysis, data curation, original draft preparation, writing, and editing. AAA: concept, methodology, formal analysis, and editing. TAA: conceptualization, methodology, and editing.

Authorship statement

We confirm that all authors meet the ICMJE and Taylor & Francis authorship criteria.

Data availability statement

Data are available upon request.

Disclosure statement

No potential conflict of interest was reported by the author(s).

Additional information

Funding

This research has been funded by the Scientific Research Deanship at the University of Ha’il-Saudi Arabia through project number (BA-23 018).