ABSTRACT
To study a case of a middle-aged male with a non-tumor-associated Epstein–Barr virus (EBV) infection associated with Anti-N-methyl-D-aspartate receptor encephalitis (NMDARE), to explore the role of EBV in the pathogenesis of anti-NMDARE. The patient was diagnosed with “Anti-NMDARE, EBV infection” by using Cerebrospinal fluid (CSF) autoimmune encephalitis profile, and Metagenomics Next-Generation Sequencing (mNGS) pathogenic microbial assays, we discuss the relationship between EBV and NMDARE by reviewed literature. EBV infection may trigger and enhance anti-NMDARE, and the higher the titer of NMDAR antibody, the more severe the clinical presentation.
Acknowledgements
We thank the patient for their support in our study.
Abbreviations
Ab | = | antibody |
BBB | = | blood-brain barrier |
CA | = | capsid antigen |
CBA | = | Cell Based Assay |
CMV | = | Cytomegalovirus |
CNS | = | central nervous system |
CSF | = | cerebrospinal fluid |
dsDNA | = | double-stranded DNA |
EA | = | early antigen |
EBV | = | Epstein-Barr virus |
EEG | = | electroencephalogram |
IIF | = | Indirect Immunofluorescence assay |
HSV | = | Herpes simplex virus |
IVIG | = | intravenous immunoglobulin |
MRI | = | Magnetic Resonance Imaging |
MRA | = | magnetic resonance angiography |
mNGS | = | Metagenomics Next-Generation Sequencing |
NA | = | nuclear-antigen |
NMDARE | = | N-methyl-D-aspartate receptor encephalitis |
NR1 | = | N-methyl-D-aspartate receptor subunit 1 |
OB | = | oligoclonal band |
PCR | = | polymerase chain reaction |
TBA | = | Tissue Based Assay |
RV | = | Rubella virus |
TBA | = | tissue based assay |
TOX | = | Toxoplasma. |
Disclosure statement
No potential conflict of interest was reported by the author(s).