Developments of possible clinical diagnostic methods for parkinson’s disease: event-related potentials

ABSTRACT

In this study, Event-Related Potential (ERP) analyzes were performed to detect cognitive impairments in PD with Deep Brain Stimulation (DBS). A total of 85 volunteers underwent ERP analysis and neuropsychological testing (NPT) to determine cognitive level. In ERP analyses, prolonged latencies were observed in PD groups. However, patients implanted with DBS showed a decrease in latencies, a decrease in symptoms and statistical improvements in both cognitive and attention skills. Considering all these data, ERP results are promising as a noninvasive method that can be used in both disease status and diagnosis of PD.

KEYWORDS:

• Event-related potentials
• ERP
• neuropsychological tests
• NPT
• Parkinson’s

Disclosure statement

No potential conflict of interest was reported by the author(s).

Availability of data and materials

The datasets used and/or analyzed during the current study are available from the corresponding author upon reasonable request.

Ethical approval and consent to participate

The ethics committee decision of the study in question was taken by the Altinbas University Clinical Research Ethics Committee.

Additional information

Funding

The authors thank the Altinbas University Scientific Research Projects Coordination Department (AU-BAP, Project Number: PB2019-TIP-5), respectively.