Terpenoids from Alpinia galanga and their acetylcholinesterase inhibitory activity

Abstract

A new labdane diterpene (1), two new norsesquiterpenoids (2-3), as well as eight known terpenoids (4-11) were isolated from the seeds of Alpinia galanga (Zingiberaceae). Their structures and absolute configurations were elucidated by 1D, 2D NMR, MS, and comparison of their experimental and calculated electronic circular dichroism (ECD). The acetylcholinesterase (AChE) inhibitory activities of all the isolated compounds (1-11) were evaluated and the result showed that compounds 6 and 9 had inhibitory activity against AChE, with IC₅₀ values at 295.70 and 183.91 μM, whereas other compounds did not show any inhibitory activity.

Graphic Abstract

Keywords:

• Alpinia galanga
• sesquiterpenoid
• diterpenoid
• acetylcholinesterase
• inhibitory activity

Acknowledgements

We thank the Instrumentation Center of Guizhou Medical University for acquisition of the NMR and high-resolution mass spectrometry data.

Disclosure statement

The authors declare no conflict of interest.

Additional information

Funding

This work was supported by the Guizhou Provincial Scientific and Technological Innovation Base (number [2023]003); the Social Development Supportive Program of Science & Technology Department of Guizhou Province under Grant (number [2018]2767).